Verify Human chorionic gonadotropin (hCG)

Drug JSON

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{
  "slug": "hcg",
  "nameEn": "Human chorionic gonadotropin (hCG)",
  "nameTh": "ฮิวแมนคอริออนิกโกนาโดโทรปิน",
  "class": "Reproductive — gonadotropin (LH-like)",
  "mechanism": "gonadotropin ที่มีฤทธิ์คล้าย LH — กระตุ้นการตกไข่ (ovulation) ในเพศเมีย และกระตุ้น Leydig cell ให้สร้าง testosterone ในเพศผู้",
  "brandNamesTh": [
    "Chorulon"
  ],
  "indications": [
    {
      "text": "เหนี่ยวนำ/จับเวลา ovulation ในกรณี delayed ovulation, รักษา libido/semen quality ในเพศผู้, ประเมินการทำงานของอัณฑะ (hCG stimulation test) ในสุนัขและแมว",
      "cites": [
        "merck-repro-overview-c",
        "ref-hcg"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ผลผันแปร โดยเฉพาะการใช้ซ้ำระยะยาว (อาจสร้าง antibody ลดประสิทธิภาพ); จับเวลาให้ตรง estrus จึงสำคัญ; เป็นโปรตีนต่างชนิด — ระวังปฏิกิริยาแพ้เมื่อให้ซ้ำ",
      "cites": [
        "ref-hcg"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมปลอดภัย; ใช้ซ้ำอาจกระตุ้น antibody ต่อ hCG; ปฏิกิริยาบริเวณฉีดเล็กน้อย",
      "cites": [
        "ref-hcg"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Delayed ovulation / ovulation induction (female)",
      "route": "IM",
      "dose": "22 IU/kg IM ทุก 24–48 ชั่วโมง หรือ 44 IU/kg IM ครั้งเดียว (ผสมพันธุ์ช่วง behavioral estrus)",
      "cites": [
        "ref-hcg",
        "merck-repro-overview-c"
      ]
    },
    {
      "species": "canine",
      "indication": "Improve semen quality (male)",
      "route": "IM",
      "dose": "100–500 IU/ตัว IM สัปดาห์ละ 2 ครั้ง นานสูงสุด 6 สัปดาห์",
      "cites": [
        "ref-hcg"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-repro-overview-c",
      "type": "textbook",
      "title": "Systemic Pharmacotherapeutics of the Reproductive System — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-reproductive-system/overview-of-systemic-pharmacotherapeutics-of-the-reproductive-system-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "ref-hcg",
      "type": "guideline",
      "title": "Chorionic gonadotropin (hCG) veterinary dosing — Vet Drugs List",
      "url": "https://www.vet-ebooks.com/vetdrugslist/chorionic-gonadotrophin-dose/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-human_chorionic_gonadotropin",
      "type": "monograph",
      "title": "Human chorionic gonadotropin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "G03GA01",
      "name": "Chorionic gonadotropin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / WSAVA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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