Verify Guaifenesin

Drug JSON

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{
  "slug": "guaifenesin",
  "nameEn": "Guaifenesin",
  "nameTh": "กไวเฟเนซิน",
  "class": "Antitussives & expectorants — centrally-acting muscle relaxant / expectorant",
  "mechanism": "ออกฤทธิ์ 2 อย่าง: (1) expectorant — เพิ่มการหลั่งของเหลวในทางเดินหายใจ ทำให้เสมหะเหลวขับง่าย; (2) centrally-acting muscle relaxant — กดการส่งสัญญาณที่ internuncial neuron ของไขสันหลัง/ก้านสมอง ใช้ในการวางยาสลบม้า",
  "brandNamesTh": [
    "Guailaxin",
    "GG",
    "Mucinex"
  ],
  "indications": [
    {
      "text": "expectorant ขับเสมหะ; centrally-acting muscle relaxant ในการเหนี่ยวนำสลบม้า (มักคู่ ketamine/thiopental) เพื่อคลายกล้ามเนื้อขณะล้มตัว",
      "cites": [
        "merck-muscle-relax-q",
        "wedgewood-guaifenesin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "รูปฉีดความเข้มข้น >5% ทำให้ hemolysis + thrombophlebitis — ใช้ ≤5% และให้ทางหลอดเลือดดำที่แน่นอน; ขนาดสูงกดการหายใจ; เป็น muscle relaxant ไม่ใช่ยาสลบ/ระงับปวดเดี่ยว (ต้องร่วมยาอื่น)",
      "cites": [
        "merck-muscle-relax-q"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "hemolysis/thrombophlebitis (ความเข้มข้นสูง), กดการหายใจ (ขนาดสูง), ความดันต่ำชั่วคราว, ล้มตัวขณะเหนี่ยวนำ",
      "cites": [
        "wedgewood-guaifenesin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "equine",
      "indication": "Anesthetic induction (centrally-acting muscle relaxant)",
      "route": "IV",
      "dose": "40–100 mg/kg IV (สารละลาย ≤5%) เพื่อเหนี่ยวนำ มักคู่ ketamine/thiopental; 5–10 mg/kg ในม้าที่สลบแล้วเพื่อคลายกล้ามเนื้อเสริม",
      "cites": [
        "merck-muscle-relax-q",
        "wedgewood-guaifenesin"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-muscle-relax-q",
      "type": "textbook",
      "title": "Skeletal Muscle Relaxants for Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-muscular-system/skeletal-muscle-relaxants-for-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wedgewood-guaifenesin",
      "type": "guideline",
      "title": "Guaifenesin for Horses — Wedgewood Pharmacy",
      "url": "https://www.wedgewood.com/medications/guaifenesin/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-guaifenesin",
      "type": "monograph",
      "title": "Guaifenesin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Guaifenesin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "R05CA03",
      "name": "Guaifenesin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / FDA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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