Verify Flunixin meglumine

Drug JSON

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{
  "slug": "flunixin",
  "nameEn": "Flunixin meglumine",
  "nameTh": "ฟลูนิกซิน เมกลูมีน",
  "class": "NSAID — non-selective COX inhibitor (large-animal analgesic/antipyretic)",
  "mechanism": "ยับยั้ง cyclooxygenase (COX-1/COX-2) ลดการสร้าง prostaglandin มีฤทธิ์แก้ปวด ลดอักเสบ และลดไข้เด่นในภาวะปวดช่องท้อง (visceral) และ endotoxemia ของม้าและโค",
  "brandNamesTh": [
    "Banamine",
    "Finadyne"
  ],
  "indications": [
    {
      "text": "อาการปวดในช่องท้อง (colic) และลดไข้/พิษจาก endotoxin ในม้า; ลดอักเสบ ปวด และไข้ในโคและสุกร",
      "cites": [
        "dailymed-flunixin",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "โรคไต/ตับ, แผลในทางเดินอาหาร, ภาวะขาดน้ำ/เลือดน้อย; ห้ามใช้ร่วมกับ NSAID หรือ corticosteroid ตัวอื่น; ต้องเว้นระยะหยุดยา (withdrawal time) ในสัตว์ที่ให้ผลผลิตเป็นอาหาร",
      "cites": [
        "dailymed-flunixin",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "แผลในทางเดินอาหาร, พิษต่อไต, ระคายเคืองเนื้อเยื่อ/กล้ามเนื้อตายหากฉีด IM (จึงแนะนำ IV ในม้า)",
      "cites": [
        "dailymed-flunixin",
        "wikipedia-Flunixin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "equine",
      "indication": "Colic / pyrexia / musculoskeletal pain",
      "route": "IV",
      "dose": "1.1 mg/kg IV (แนะนำ) / IM / PO ทุก 12–24 ชั่วโมง — ใช้ไม่เกิน ~5 วัน",
      "cites": [
        "plumbs",
        "dailymed-flunixin"
      ]
    },
    {
      "species": "bovine",
      "indication": "Fever / inflammation / endotoxemia",
      "route": "IV",
      "dose": "2.2 mg/kg IV ทุก 24 ชั่วโมง (หรือ 1.1 mg/kg q12h) สูงสุด 3 วัน",
      "cites": [
        "plumbs",
        "dailymed-flunixin"
      ]
    },
    {
      "species": "canine",
      "indication": "Acute pain / antipyretic (single use)",
      "route": "IV",
      "dose": "1.1 mg/kg IV/SC ครั้งเดียว — ⚠️ ความเสี่ยง GI/ไตสูง ไม่ใช้ต่อเนื่อง มี NSAID สำหรับสุนัขที่ปลอดภัยกว่า",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-QM01AG90",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Flunixin (veterinary) (QM01AG90)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QM01AG90&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical (incl. ATCvet Q-codes) classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-flunixin",
      "type": "package-insert",
      "title": "Flunixin meglumine — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=flunixin",
      "note": "US FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled dose.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Flunixin",
      "type": "monograph",
      "title": "Flunixin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Flunixin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QM01AG90",
      "name": "Flunixin (veterinary)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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