Verify Fludrocortisone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "fludrocortisone",
  "nameEn": "Fludrocortisone",
  "nameTh": "ฟลูโดรคอร์ติโซน",
  "class": "Adrenal — mineralocorticoid replacement",
  "mechanism": "corticosteroid สังเคราะห์ที่มีฤทธิ์ mineralocorticoid เด่น (ออกฤทธิ์ที่ไตเพิ่มการดูดกลับ Na+ และขับ K+); ใช้ทดแทนในภาวะต่อมหมวกไตทำงานบกพร่อง (Addison's)",
  "brandNamesTh": [
    "Florinef"
  ],
  "indications": [
    {
      "text": "รักษาภาวะต่อมหมวกไตวายเรื้อรัง (hypoadrenocorticism / Addison's disease) ชนิดที่ต้องการ mineralocorticoid ในสุนัข (ทางเลือกแบบกินเทียบกับ DOCP ฉีด)",
      "cites": [
        "merck-addison-i",
        "vca-fludrocortisone"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ต้องปรับขนาดตาม Na+/K+ เป็นรายตัว; บางตัวต้องเสริม glucocorticoid (prednisolone) ร่วม; ระวังในหัวใจล้มเหลว/ความดันสูง (Na retention)",
      "cites": [
        "merck-addison-i"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "PU/PD, ความดันสูง, K+ ต่ำ, บวมน้ำเมื่อขนาดสูง; คุม electrolyte ไม่ได้ถ้าขนาดต่ำเกิน",
      "cites": [
        "vca-fludrocortisone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Hypoadrenocorticism (Addison's)",
      "route": "PO",
      "dose": "เริ่ม 0.01–0.02 mg/kg PO วันละครั้ง (หรือแบ่ง BID) แล้วปรับตาม Na+/K+ ทุก 1–2 สัปดาห์",
      "cites": [
        "merck-addison-i",
        "vca-fludrocortisone"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ Na+/K+ (เป้า Na:K > 27) ทุก 1–2 สัปดาห์ช่วงปรับขนาด แล้วทุก 3–6 เดือน",
      "cites": [
        "merck-addison-i"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-addison-i",
      "type": "textbook",
      "title": "Hypoadrenocorticism (Addison Disease) — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/endocrine-system/the-adrenal-glands/hypoadrenocorticism-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vca-fludrocortisone",
      "type": "monograph",
      "title": "Fludrocortisone — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/fludrocortisone-acetate",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-fludrocortisone",
      "type": "monograph",
      "title": "Fludrocortisone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Fludrocortisone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H02AA02",
      "name": "Fludrocortisone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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