Verify Flucytosine (5-FC)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "flucytosine",
  "nameEn": "Flucytosine (5-FC)",
  "nameTh": "ฟลูไซโตซีน (5-FC)",
  "class": "Antifungal — pyrimidine analogue",
  "mechanism": "ถูกเปลี่ยนเป็น 5-fluorouracil ในเซลล์เชื้อรา ขัดขวางการสร้าง RNA/DNA ใช้ร่วมกับ amphotericin/azole รักษา cryptococcosis (โดยเฉพาะ CNS)",
  "brandNamesTh": [
    "Ancobon"
  ],
  "indications": [
    {
      "text": "โรค cryptococcosis (โดยเฉพาะที่ระบบประสาท/จมูกในแมว) — ใช้ร่วม amphotericin B หรือ fluconazole เสมอ",
      "cites": [
        "dailymed-flucytosine",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามใช้เดี่ยว (ดื้อยาเร็วมาก) — ต้องร่วมยาต้านเชื้อราอื่น; กดไขกระดูก; ปรับขนาดในโรคไต; ผื่นผิวหนังรุนแรงในสุนัข",
      "cites": [
        "dailymed-flucytosine",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, อาเจียน/ท้องเสีย, ผื่นผิวหนัง (drug eruption รุนแรงในสุนัข), เอนไซม์ตับขึ้น",
      "cites": [
        "plumbs",
        "wikipedia-Flucytosine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Cryptococcosis (with amphotericin/azole)",
      "route": "PO",
      "dose": "25–50 mg/kg PO ทุก 6–8 ชั่วโมง ร่วมยาต้านเชื้อราอื่นเสมอ",
      "cites": [
        "plumbs",
        "dailymed-flucytosine"
      ]
    },
    {
      "species": "canine",
      "indication": "Cryptococcosis (with amphotericin/azole)",
      "route": "PO",
      "dose": "25–50 mg/kg PO ทุก 6–8 ชั่วโมง — ระวังผื่นผิวหนัง",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-J02AX01",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Flucytosine (J02AX01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=J02AX01&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-flucytosine",
      "type": "package-insert",
      "title": "Flucytosine — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=flucytosine",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Flucytosine",
      "type": "monograph",
      "title": "Flucytosine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Flucytosine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J02AX01",
      "name": "Flucytosine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / VSSO), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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