Verify Finasteride

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "finasteride",
  "nameEn": "Finasteride",
  "nameTh": "ฟิแนสเตอไรด์",
  "class": "Reproductive — 5α-reductase inhibitor (BPH)",
  "mechanism": "ยับยั้งเอนไซม์ 5α-reductase type II ที่เปลี่ยน testosterone เป็น dihydrotestosterone (DHT) — ลด DHT ทำให้ต่อมลูกหมากที่โตจาก hormone หดเล็กลง โดยไม่กระทบ testosterone หรือคุณภาพน้ำเชื้อ",
  "brandNamesTh": [
    "Proscar",
    "Finapet"
  ],
  "indications": [
    {
      "text": "ต่อมลูกหมากโตชนิดไม่ใช่มะเร็ง (benign prostatic hyperplasia, BPH) ในสุนัขเพศผู้ — ลดขนาดต่อมลูกหมากโดยไม่ลดคุณภาพน้ำเชื้อ (เหมาะกับสุนัขพ่อพันธุ์)",
      "cites": [
        "merck-bph",
        "paper-finasteride"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ teratogenic — ผู้หญิงตั้งครรภ์ห้ามสัมผัสเม็ดที่บด (เสี่ยงต่อทารกเพศชาย); ต้องใช้ต่อเนื่องตลอด (หยุดแล้วต่อมลูกหมากโตกลับ); ทางเลือกถาวรคือทำหมัน",
      "cites": [
        "merck-bph",
        "paper-finasteride"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมทนได้ดี ไม่กระทบ testosterone/semen; ผลกลับคืนเมื่อหยุดยา (ต่อมโตซ้ำ)",
      "cites": [
        "paper-finasteride"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Benign prostatic hyperplasia (male)",
      "route": "PO",
      "dose": "0.1–0.5 mg/kg PO วันละครั้ง (หรือ 5 mg/ตัว สำหรับสุนัข 10–50 kg); ผลเห็นใน ~16 สัปดาห์",
      "cites": [
        "merck-bph",
        "paper-finasteride"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ติดตามขนาดต่อมลูกหมาก (อัลตราซาวด์) + อาการทางคลินิก; ต้องใช้ต่อเนื่อง",
      "cites": [
        "merck-bph"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-bph",
      "type": "textbook",
      "title": "Benign Prostatic Hyperplasia in Dogs and Cats — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/reproductive-system/prostatic-diseases/benign-prostatic-hyperplasia-in-dogs-and-cats",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "paper-finasteride",
      "type": "paper",
      "title": "Effects of finasteride on prostate size and semen quality in dogs with BPH (JAVMA 2001)",
      "url": "https://pubmed.ncbi.nlm.nih.gov/11330612/",
      "year": 2023,
      "note": "Peer-reviewed canine finasteride BPH study.",
      "cid": null
    },
    {
      "id": "wikipedia-finasteride",
      "type": "monograph",
      "title": "Finasteride — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Finasteride",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "G04CB01",
      "name": "Finasteride",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / WSAVA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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