Verify Felbamate

Drug JSON

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{
  "slug": "felbamate",
  "nameEn": "Felbamate",
  "nameTh": "เฟลบาเมต",
  "class": "Anticonvulsant — dicarbamate (add-on)",
  "mechanism": "ออกฤทธิ์หลายกลไก — ยับยั้ง NMDA receptor และเสริม GABA; ใช้เสริม (add-on) ในการชักที่ดื้อยา ข้อดีคือไม่ค่อยกดประสาทและไม่กระทบ phenobarbital level",
  "brandNamesTh": [
    "Felbatol"
  ],
  "indications": [
    {
      "text": "การชักที่ดื้อยา (refractory epilepsy) ในสุนัข — เป็นยาเสริม โดยเฉพาะ focal seizures; margin of safety กว้าง",
      "cites": [
        "merck-anticonvulsant-j",
        "tvp-epilepsy"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ พิษตับ (โดยเฉพาะใช้ร่วม phenobarbital) — ตรวจตับ; blood dyscrasia (leukopenia/thrombocytopenia); keratoconjunctivitis sicca (ตาแห้ง); ปรับในตับบกพร่อง; ห้ามหยุดกะทันหัน",
      "cites": [
        "merck-anticonvulsant-j",
        "tvp-epilepsy"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ตัวสั่น น้ำลายมาก กระสับกระส่าย (ขนาดสูง), ตาแห้ง (KCS), พิษตับ, เม็ดเลือดผิดปกติ; ไม่ค่อยกดประสาท",
      "cites": [
        "tvp-epilepsy"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Refractory epilepsy (add-on)",
      "route": "PO",
      "dose": "15–20 mg/kg PO ทุก 8 ชั่วโมง; เพิ่มทีละ 15 mg/kg ทุก 2 สัปดาห์ตามต้องการ (สูงสุด ~70 mg/kg q8h)",
      "cites": [
        "merck-anticonvulsant-j",
        "tvp-epilepsy"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าตับ + CBC + ตา (Schirmer) ทุก ~6 เดือน โดยเฉพาะเมื่อใช้ร่วม phenobarbital",
      "cites": [
        "tvp-epilepsy"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-anticonvulsant-j",
      "type": "textbook",
      "title": "Anticonvulsants for Treatment of Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-nervous-system/anticonvulsants-for-treatment-of-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tvp-epilepsy",
      "type": "guideline",
      "title": "Antiseizure Medications for Dogs and Cats — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pharmacology/antiseizure-medications-for-dogs-and-cats/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-felbamate",
      "type": "monograph",
      "title": "Felbamate — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Felbamate",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N03AX10",
      "name": "Felbamate",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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