Verify Intravenous lipid emulsion (ILE)

Drug JSON

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{
  "slug": "fat-emulsion",
  "nameEn": "Intravenous lipid emulsion (ILE)",
  "nameTh": "สารอิมัลชันไขมันทางหลอดเลือด (ILE)",
  "class": "Lipid-sink antidote / parenteral nutrition",
  "mechanism": "สร้าง “lipid compartment” ในเลือดที่ดึงยา/สารพิษที่ละลายในไขมันออกจากเนื้อเยื่อเป้าหมาย (lipid-sink) และอาจช่วยพลังงานหัวใจ ใช้แก้พิษสารลิโพฟิลิก",
  "brandNamesTh": [
    "Intralipid",
    "SMOFlipid"
  ],
  "indications": [
    {
      "text": "แก้พิษเฉียบพลันจากสารที่ละลายในไขมัน (local anesthetic เช่น bupivacaine, permethrin ในแมว, ivermectin, baclofen, CCB/β-blocker, NSAID บางชนิด); ใช้เป็น parenteral nutrition ด้วย",
      "cites": [
        "dailymed-fat emulsion intravenous",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในภาวะไขมันในเลือดสูง/ตับอ่อนอักเสบ; ⚠️ ขนาดสูงเกินเสี่ยง fat overload (เม็ดเลือดแดงแตก, ปอดเสียหาย); ใช้สายและอุปกรณ์สะอาดป้องกันการติดเชื้อ",
      "cites": [
        "dailymed-fat emulsion intravenous",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "fat overload syndrome (ในขนาดสูง), ไขมันในเลือดสูงชั่วคราว, ติดเชื้อจากสาย, ปฏิกิริยาแพ้",
      "cites": [
        "plumbs",
        "wikipedia-Lipid_emulsion"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lipophilic toxicosis (lipid rescue)",
      "route": "IV",
      "dose": "20% emulsion: bolus 1.5 mL/kg IV แล้ว CRI 0.25 mL/kg/min นาน 30–60 นาที (ให้ซ้ำตามอาการ ติดตามซีรัมว่าใส)",
      "cites": [
        "plumbs",
        "dailymed-fat emulsion intravenous"
      ]
    },
    {
      "species": "feline",
      "indication": "Lipophilic toxicosis (e.g. permethrin)",
      "route": "IV",
      "dose": "20% emulsion: bolus 1.5 mL/kg IV แล้ว CRI 0.25 mL/kg/min นาน 30–60 นาที",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-B05BA02",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Fat emulsion (intravenous lipid emulsion) (B05BA02)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=B05BA02&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-fat emulsion intravenous",
      "type": "package-insert",
      "title": "Intravenous fat emulsion — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=fat%20emulsion%20intravenous",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Lipid_emulsion",
      "type": "monograph",
      "title": "Lipid emulsion — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Lipid_emulsion",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "B05BA02",
      "name": "Fat emulsion (intravenous lipid emulsion)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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