Verify Famotidine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "famotidine",
  "nameEn": "Famotidine",
  "nameTh": "ฟาโมทิดีน",
  "class": "H2-receptor antagonist — acid suppression",
  "mechanism": "ยับยั้ง histamine H2 receptor ที่ parietal cell ลดการหลั่งกรด; ออกฤทธิ์อ่อนกว่า PPI และเกิด tolerance เมื่อใช้ต่อเนื่อง",
  "brandNamesTh": [
    "Pepcid"
  ],
  "indications": [
    {
      "text": "ลดกรดในกระเพาะ ใช้กับ gastritis และแผลในทางเดินอาหารระดับเบา–ปานกลาง; PPI (omeprazole) เหนือกว่าในรอยโรครุนแรง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ปรับลดขนาดในสัตว์ไตบกพร่อง (ขับทางไต); ประสิทธิภาพลดลงเมื่อใช้ต่อเนื่อง (tachyphylaxis)",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมปลอดภัย; การให้ IV เร็วอาจสัมพันธ์กับ hemolysis (รายงานในแมว); ประสิทธิภาพคุมกรดด้อยกว่า PPI",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Acid suppression / mild ulcer",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO/IV ทุก 12–24 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant",
        "merck-antiulcer"
      ]
    },
    {
      "species": "feline",
      "indication": "Acid suppression / mild ulcer",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO/IV ทุก 12–24 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "citations": [
    {
      "id": "acvim-gi-protectant",
      "type": "guideline",
      "title": "ACVIM Consensus Statement: Rational administration of gastrointestinal protectants to dogs and cats",
      "authors": "Marks SL, et al.",
      "year": 2018,
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6271318/",
      "note": "Peer-reviewed ACVIM consensus (J Vet Intern Med) — PPI/H2/sucralfate evidence + dosing. Authoritative.",
      "cid": null
    },
    {
      "id": "merck-antiulcer",
      "type": "textbook",
      "title": "Antiulcerative Drugs — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/multimedia/table/antiulcerative-drugs",
      "note": "Merck antiulcerative dosing table. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-famotidine",
      "type": "regulatory-database",
      "title": "Famotidine — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=famotidine",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "00ce3810b7932daa591a6033c8283a69c33b6e24f05d9ffda29af6a572aad345"
    },
    {
      "id": "atc-A02BA03",
      "type": "guideline",
      "title": "ATC A02BA03 — Famotidine",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=A02BA03&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "482be17546ef61097a8e1659ce6feeed790fe3ab14088ada1e8ab9768c3c2b78"
    },
    {
      "id": "pubchem-famotidine",
      "type": "monograph",
      "title": "Famotidine — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Famotidine",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "5e892353805c3d0a025083513749b91037bf40609f5358438a65dacc85dc6eb3"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=famotidine",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=A02BA03&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Famotidine",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "00ce3810b7932daa591a6033c8283a69c33b6e24f05d9ffda29af6a572aad345",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "482be17546ef61097a8e1659ce6feeed790fe3ab14088ada1e8ab9768c3c2b78",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "5e892353805c3d0a025083513749b91037bf40609f5358438a65dacc85dc6eb3",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "A02BA03",
      "name": "Famotidine",
      "level": 5
    },
    "rxnorm": {
      "cui": "4278",
      "name": "Famotidine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC A02BA03 + RxNorm 4278. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — famotidine 0.5–1 mg/kg q12–24h verified against ACVIM consensus + Merck antiulcerative table. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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