Verify Estriol

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "estriol",
  "nameEn": "Estriol",
  "nameTh": "เอสไตรออล",
  "class": "Reproductive — short-acting estrogen (urinary incontinence)",
  "mechanism": "short-acting natural estrogen — เพิ่มความตึงตัวและการตอบสนองต่อ alpha-receptor ของหูรูดท่อปัสสาวะ จึงคุมการกลั้นปัสสาวะใน estrogen-responsive incontinence (USMI)",
  "brandNamesTh": [
    "Incurin"
  ],
  "indications": [
    {
      "text": "ภาวะกลั้นปัสสาวะไม่อยู่ที่ตอบสนองต่อ estrogen (urethral sphincter mechanism incompetence, USMI) ในสุนัขเพศเมียที่ทำหมันแล้ว (Incurin, FDA-approved)",
      "cites": [
        "fda-incurin",
        "merck-incontinence"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ใช้ขนาดต่ำสุดที่คุมได้ (ขนาดสูง/นานเสี่ยงกดไขกระดูกแบบ estrogen — แม้ estriol short-acting เสี่ยงน้อยกว่า estradiol); ห้ามในสัตว์ที่ยังไม่ทำหมัน/ตั้งท้อง; ไม่ขึ้นกับน้ำหนักตัว",
      "cites": [
        "fda-incurin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เบื่ออาหาร อาเจียน ดื่มน้ำมาก ปากช่องคลอดบวม; estrogenic signs เมื่อขนาดสูง",
      "cites": [
        "fda-incurin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Estrogen-responsive urinary incontinence (spayed female)",
      "route": "PO",
      "dose": "เริ่ม 2 mg/ตัว PO วันละครั้ง อย่างน้อย 14 วัน แล้วลดเหลือขนาดต่ำสุดที่คุมได้ (อาจวันเว้นวัน); ไม่เกิน 2 mg/วัน",
      "cites": [
        "fda-incurin",
        "merck-incontinence"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-incurin",
      "type": "package-insert",
      "title": "Incurin (estriol) — FDA/Merck veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/incurin-tablets.html",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "merck-incontinence",
      "type": "textbook",
      "title": "Pharmacotherapeutics in Urinary Incontinence in Dogs and Cats — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-urinary-system/pharmacotherapeutics-in-urinary-incontinence-in-dogs-and-cats",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-estriol",
      "type": "monograph",
      "title": "Estriol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Estriol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "G03CA04",
      "name": "Estriol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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