Verify Esomeprazole

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "esomeprazole",
  "nameEn": "Esomeprazole",
  "nameTh": "เอสโซเมพราโซล",
  "class": "GI — proton pump inhibitor",
  "mechanism": "S-enantiomer ของ omeprazole ยับยั้งปั๊มโปรตอน H+/K+-ATPase ที่ parietal cell ลดการหลั่งกรดได้แรงและสม่ำเสมอ; มีรูป IV สำหรับสัตว์ที่กินไม่ได้",
  "brandNamesTh": [
    "Nexium"
  ],
  "indications": [
    {
      "text": "แผลและเลือดออกในทางเดินอาหาร, esophagitis/reflux, gastritis ในสุนัขและแมว — ทางเลือกของ omeprazole โดยเฉพาะเมื่อต้องการ IV",
      "cites": [
        "merck-gi-i",
        "acvim-gi-i"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "หลีกเลี่ยงหยุดกะทันหันหลังใช้นาน (rebound hyperacidity — ค่อย ๆ ลด); ใช้นานอาจกระทบการดูดซึมสารอาหาร/microbiome; ปรับในตับบกพร่องรุนแรง",
      "cites": [
        "acvim-gi-i"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมปลอดภัย; ใช้นานเสี่ยง dysbiosis + ลดดูดซึมแร่ธาตุ; rebound เมื่อหยุดกะทันหัน",
      "cites": [
        "merck-gi-i"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "GI ulcer / esophagitis",
      "route": "PO",
      "dose": "1 mg/kg PO/IV ทุก 24 ชั่วโมง (เคสรุนแรง q12h)",
      "cites": [
        "merck-gi-i",
        "acvim-gi-i"
      ]
    },
    {
      "species": "feline",
      "indication": "GI ulcer / esophagitis",
      "route": "PO",
      "dose": "1 mg/kg PO/IV ทุก 24 ชั่วโมง",
      "cites": [
        "acvim-gi-i"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-gi-i",
      "type": "textbook",
      "title": "Drugs for Gastrointestinal Ulcers — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-used-to-treat-gastrointestinal-ulcers-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "acvim-gi-i",
      "type": "guideline",
      "title": "ACVIM Consensus: rational administration of GI protectants",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6271318/",
      "year": 2024,
      "note": "ACVIM/AAHA consensus or guideline.",
      "cid": null
    },
    {
      "id": "wikipedia-esomeprazole",
      "type": "monograph",
      "title": "Esomeprazole — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Esomeprazole",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A02BC05",
      "name": "Esomeprazole",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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