Verify Epinephrine (adrenaline)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "epinephrine",
  "nameEn": "Epinephrine (adrenaline)",
  "nameTh": "อิพิเนฟริน (อะดรีนาลีน)",
  "class": "Emergency — adrenergic agonist (CPR / anaphylaxis)",
  "mechanism": "กระตุ้น α- และ β-adrenergic receptor ทำให้หลอดเลือดหดตัว (เพิ่ม coronary/cerebral perfusion ระหว่าง CPR), เพิ่มแรงและอัตราการเต้นหัวใจ, ขยายหลอดลม; ยาหลักของ cardiac arrest และ anaphylaxis",
  "brandNamesTh": [
    "Adrenaline"
  ],
  "indications": [
    {
      "text": "หัวใจหยุดเต้น (cardiac arrest, CPR), ภาวะแพ้รุนแรง (anaphylaxis); เป็นยา first-line ใน RECOVER CPR algorithm",
      "cites": [
        "recover-2024",
        "bsava-emergency"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "นอกบริบทฉุกเฉินต้องระวังมาก (กระตุ้น tachyarrhythmia, ความดันสูงรุนแรง); high-dose epinephrine ไม่แนะนำใน CPR ทั่วไป",
      "cites": [
        "recover-2024"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นเร็ว/arrhythmia, ความดันสูง, กล้ามเนื้อหัวใจขาดเลือด; ใช้เฉพาะเมื่อมีข้อบ่งชี้ชัด",
      "cites": [
        "recover-2024"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "CPR (cardiac arrest)",
      "route": "IV",
      "dose": "low-dose 0.01 mg/kg IV/IO ทุก 3–5 นาที (1:10,000); อาจให้ทาง intratracheal หากไม่มี IV",
      "cites": [
        "recover-2024",
        "bsava-emergency"
      ]
    },
    {
      "species": "canine",
      "indication": "Anaphylaxis",
      "route": "IM",
      "dose": "0.01 mg/kg IM (1:1,000) ซ้ำได้ตามอาการ",
      "cites": [
        "bsava-emergency"
      ]
    }
  ],
  "citations": [
    {
      "id": "recover-2024",
      "type": "guideline",
      "title": "RECOVER 2024 CPR Drug Dosing Charts (Reassessment Campaign on Veterinary Resuscitation)",
      "year": 2024,
      "url": "https://recoverinitiative.org/wp-content/uploads/2024/07/RECOVER-2024-Drug-Dosing-Charts-LBS.pdf",
      "note": "Consensus veterinary CPR dosing charts. Authoritative emergency reference.",
      "cid": null
    },
    {
      "id": "bsava-emergency",
      "type": "guideline",
      "title": "Emergency doses for dogs and cats — BSAVA Formulary",
      "year": 2025,
      "url": "https://www.bsavalibrary.com/content/formulary/backmatter/canine-and-felineemergencydosesfordogsandcats",
      "note": "BSAVA emergency drug dosing table. Authoritative reference.",
      "cid": null
    },
    {
      "id": "wikipedia-Epinephrine",
      "type": "monograph",
      "title": "Epinephrine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Epinephrine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01CA24",
      "name": "Epinephrine (adrenaline)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (RECOVER 2024 / BSAVA / Merck / AAHA / ACVIM / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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