Verify Doxapram

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "doxapram",
  "nameEn": "Doxapram",
  "nameTh": "ด็อกซาแพรม",
  "class": "Respiratory stimulant — central analeptic",
  "mechanism": "กระตุ้นศูนย์การหายใจที่ก้านสมอง (และ carotid chemoreceptor) เพิ่มอัตราและความลึกของการหายใจ; ใช้กระตุ้นการหายใจในลูกสัตว์แรกเกิดและภาวะหายใจกด",
  "brandNamesTh": [
    "Dopram"
  ],
  "indications": [
    {
      "text": "กระตุ้นการหายใจในลูกสัตว์แรกเกิดหลังคลอด/ผ่าคลอด และภาวะหายใจถูกกดจากยาสลบ; ปัจจุบันใช้ลดลง (RECOVER แนะนำ stimulation/airway ก่อน)",
      "cites": [
        "merck-resp-stim",
        "bsava-emergency"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในภาวะชัก (กระตุ้น CNS), ความดันสูง, หัวใจเต้นผิดจังหวะ; ไม่ใช่ทางแก้ที่ทดแทนการช่วยหายใจ/ออกซิเจน",
      "cites": [
        "merck-resp-stim"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กระตุ้น CNS มากเกิน (ชัก), หัวใจเต้นเร็ว, ความดันสูง; ออกฤทธิ์สั้น",
      "cites": [
        "merck-resp-stim"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Neonatal/respiratory stimulation",
      "route": "IV",
      "dose": "1–5 mg/kg IV; ลูกสัตว์แรกเกิด 1–2 หยดใต้ลิ้นหรือ 0.1 mL ต่อตัว",
      "cites": [
        "bsava-emergency",
        "merck-resp-stim"
      ]
    },
    {
      "species": "feline",
      "indication": "Neonatal/respiratory stimulation",
      "route": "IV",
      "dose": "1–5 mg/kg IV; ลูกแมวแรกเกิดขนาดเล็กตามน้ำหนัก",
      "cites": [
        "bsava-emergency"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-resp-stim",
      "type": "textbook",
      "title": "Respiratory Stimulants — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-respiratory-system",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "bsava-emergency",
      "type": "guideline",
      "title": "Emergency doses for dogs and cats — BSAVA Formulary",
      "year": 2025,
      "url": "https://www.bsavalibrary.com/content/formulary/backmatter/canine-and-felineemergencydosesfordogsandcats",
      "note": "BSAVA emergency drug dosing table. Authoritative reference.",
      "cid": null
    },
    {
      "id": "wikipedia-Doxapram",
      "type": "monograph",
      "title": "Doxapram — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Doxapram",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "R07AB01",
      "name": "Doxapram",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (RECOVER 2024 / BSAVA / Merck / AAHA / ACVIM / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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