Verify Doramectin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "doramectin",
  "nameEn": "Doramectin",
  "nameTh": "โดราเมกติน",
  "class": "Endectocide — avermectin (macrocyclic lactone)",
  "mechanism": "จับ glutamate-gated chloride channel ของพยาธิและสัตว์ขาปล้อง เพิ่ม chloride influx ทำให้เป็นอัมพาตและตาย ครอบคลุมทั้งพยาธิภายในและภายนอก (endectocide)",
  "brandNamesTh": [
    "Dectomax"
  ],
  "indications": [
    {
      "text": "ถ่ายพยาธิตัวกลม พยาธิปอด และกำจัดเหา ไร เห็บ ในโคและสุกร (รูปฉีด/ราดหลัง); ใช้ off-label รักษา demodicosis ในสุนัข",
      "cites": [
        "dailymed-doramectin",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ระวังในสุนัขพันธุ์ที่มี MDR1 (ABCB1) mutation เช่น Collie (เสี่ยงพิษระบบประสาทจาก macrocyclic lactone); เว้นระยะหยุดยาในสัตว์ผลิตอาหาร",
      "cites": [
        "dailymed-doramectin",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เจ็บบริเวณฉีด; พิษระบบประสาท (ซึม เดินเซ น้ำลายไหล ตาบอด) ในสัตว์ MDR1 หรือเกินขนาด",
      "cites": [
        "plumbs",
        "wikipedia-Doramectin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "bovine",
      "indication": "Endo/ectoparasites",
      "route": "SC",
      "dose": "0.2 mg/kg SC หรือ pour-on 0.5 mg/kg (ราดหลัง)",
      "cites": [
        "plumbs",
        "dailymed-doramectin"
      ]
    },
    {
      "species": "canine",
      "indication": "Generalized demodicosis (off-label)",
      "route": "SC",
      "dose": "~0.6 mg/kg SC/PO สัปดาห์ละครั้ง — ⚠️ คัดกรอง MDR1 ก่อน",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-QP54AA03",
      "type": "regulatory-database",
      "title": "WHO ATC/ATCvet Index — Doramectin (QP54AA03)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QP54AA03&showdescription=no",
      "note": "WHO ATC/ATCvet classification. Code verified against Wikipedia drug infobox. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-doramectin",
      "type": "package-insert",
      "title": "Doramectin (Dectomax) — DailyMed (FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=doramectin",
      "note": "FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Doramectin",
      "type": "monograph",
      "title": "Doramectin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Doramectin",
      "note": "Tertiary cross-check for class + mechanism + ATCvet code. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/ATCvet Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QP54AA03",
      "name": "Doramectin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATCvet / FDA label / Plumb’s), cross-checked. ATCvet code verified against Wikipedia infobox. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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