Verify Domperidone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "domperidone",
  "nameEn": "Domperidone",
  "nameTh": "ดอมเพอริโดน",
  "class": "GI — peripheral dopamine antagonist (prokinetic)",
  "mechanism": "dopamine D2 antagonist ที่ไม่ผ่าน blood-brain barrier — เพิ่มการบีบตัวของกระเพาะ/ลำไส้ส่วนต้น (prokinetic) โดยไม่ก่อผล CNS แบบ metoclopramide; ในม้าใช้แก้ fescue toxicosis",
  "brandNamesTh": [
    "Motilium",
    "Equidone (ม้า)"
  ],
  "indications": [
    {
      "text": "กระตุ้นการบีบตัวกระเพาะ (gastric stasis, delayed emptying) ในสุนัขและแมว (off-label, ผลผันแปร), แก้ fescue toxicosis และเพิ่มน้ำนมในม้า (Equidone)",
      "cites": [
        "merck-prokinetic",
        "vetdepot-domperidone"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยืด QT interval — เพิ่มเสี่ยง arrhythmia (ถูกถอนจากตลาดคนในสหรัฐฯ ด้วยเหตุนี้); ระวังในโรคหัวใจ/ใช้ร่วมยายืด QT; ประสิทธิภาพ prokinetic ในสัตว์เล็กยังถกเถียง",
      "cites": [
        "merck-prokinetic",
        "vetdepot-domperidone"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "QT prolongation (เสี่ยง arrhythmia), เพิ่ม prolactin (galactorrhea); CNS น้อยกว่า metoclopramide (ไม่ผ่าน BBB)",
      "cites": [
        "vetdepot-domperidone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Prokinetic (gastric stasis, off-label)",
      "route": "PO",
      "dose": "0.05–0.1 mg/kg PO วันละ 1–2 ครั้ง (≈ 2–5 mg/ตัว)",
      "cites": [
        "merck-prokinetic",
        "vetdepot-domperidone"
      ]
    },
    {
      "species": "feline",
      "indication": "Prokinetic (off-label)",
      "route": "PO",
      "dose": "0.05–0.1 mg/kg PO วันละ 1–2 ครั้ง",
      "cites": [
        "vetdepot-domperidone"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-prokinetic",
      "type": "textbook",
      "title": "Gastrointestinal Prokinetic Drugs Used in Monogastric Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/gastrointestinal-prokinetic-drugs-used-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vetdepot-domperidone",
      "type": "guideline",
      "title": "Domperidone medication guide — VetDepot",
      "url": "http://explore.vetdepot.com/medications/Domperidone/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-domperidone",
      "type": "monograph",
      "title": "Domperidone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Domperidone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A03FA03",
      "name": "Domperidone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / FDA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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