Verify Dolasetron

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "dolasetron",
  "nameEn": "Dolasetron",
  "nameTh": "โดลาเซตรอน",
  "class": "Anti-emetic — 5-HT3 receptor antagonist",
  "mechanism": "ปิดกั้น serotonin 5-HT3 receptor ทั้งส่วนกลาง (chemoreceptor trigger zone) และส่วนปลาย (vagal afferent ในลำไส้) ยับยั้งการอาเจียน; กลุ่มเดียวกับ ondansetron แต่ให้วันละครั้ง",
  "brandNamesTh": [
    "Anzemet"
  ],
  "indications": [
    {
      "text": "อาเจียน/คลื่นไส้ที่ดื้อยา โดยเฉพาะจากเคมีบำบัด, ไตวาย, pancreatitis, parvovirus ในสุนัขและแมว — ให้ก่อนเคมีบำบัด 30 นาที",
      "cites": [
        "merck-emesis-j",
        "ref-dolasetron"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวัง ECG changes (PR/QT prolongation, QRS widening จาก metabolite block Na channel) — ใช้ระวังในโรคหัวใจ/ร่วมยา arrhythmogenic; ปรับในตับบกพร่อง",
      "cites": [
        "ref-dolasetron"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมทนได้ดี; ECG interval prolongation ที่ขนาดสูง; ปวด/บวมจุดฉีด",
      "cites": [
        "ref-dolasetron"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Vomiting / chemo-induced nausea",
      "route": "IV",
      "dose": "0.6–1 mg/kg IV/PO วันละครั้ง (หรือ 30 นาทีก่อนเคมีบำบัด)",
      "cites": [
        "merck-emesis-j",
        "ref-dolasetron"
      ]
    },
    {
      "species": "feline",
      "indication": "Vomiting / chemo-induced nausea",
      "route": "IV",
      "dose": "0.6–1 mg/kg IV/PO วันละครั้ง",
      "cites": [
        "ref-dolasetron"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-emesis-j",
      "type": "textbook",
      "title": "Drugs Used to Control or Stimulate Vomiting in Monogastric Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-used-to-control-or-stimulate-vomiting-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "ref-dolasetron",
      "type": "guideline",
      "title": "Dolasetron (Anzemet) veterinary antiemetic dosing",
      "url": "https://wendyblount.com/handouts-drugs/DrugHandout-Dolasetron.pdf",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-dolasetron",
      "type": "monograph",
      "title": "Dolasetron — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Dolasetron",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A04AA04",
      "name": "Dolasetron",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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