Verify Desoxycorticosterone pivalate (DOCP)

Drug JSON

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{
  "slug": "docp",
  "nameEn": "Desoxycorticosterone pivalate (DOCP)",
  "nameTh": "ดีอ็อกซีคอร์ติโคสเตอโรน (DOCP)",
  "class": "Adrenal — mineralocorticoid replacement (canine Addison)",
  "mechanism": "mineralocorticoid ออกฤทธิ์ยาว (depot injection) ทดแทน aldosterone ในภาวะ hypoadrenocorticism (Addison); ควบคุมสมดุล Na/K โดยให้ร่วม glucocorticoid (prednisolone) แยกต่างหาก",
  "brandNamesTh": [
    "Percorten-V",
    "Zycortal"
  ],
  "indications": [
    {
      "text": "รักษา primary hypoadrenocorticism (Addison) ในสุนัข — ทดแทน mineralocorticoid; ต้องให้ glucocorticoid (prednisolone 0.2–0.4 mg/kg/วัน) ร่วมด้วย",
      "cites": [
        "fda-docp",
        "aaha-endocrine-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ในภาวะหัวใจล้มเหลว/บวมน้ำ; ปรับขนาดและช่วงห่างตาม Na/K ของแต่ละตัว",
      "cites": [
        "fda-docp"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "PU/PD, ในขนาดสูงอาจเกิด Na คั่ง/บวมน้ำ; โดยรวมทนได้ดีเมื่อปรับขนาดเหมาะสม",
      "cites": [
        "fda-docp"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Hypoadrenocorticism (Addison)",
      "route": "SC",
      "dose": "เริ่ม 2.2 mg/kg SC/IM ทุก ~25 วัน (label); งานวิจัยสนับสนุน low-dose 1.1–1.5 mg/kg ในหลายเคส",
      "notes": "ปรับขนาด+ช่วงห่างตาม Na/K ที่ ~10 และ ~25 วัน; ให้ prednisolone ร่วม",
      "cites": [
        "fda-docp",
        "paper-docp-lowdose"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ Na/K ที่วันที่ 10 (peak) และวันที่ 25 (trough) หลังฉีดเพื่อปรับขนาดและช่วงห่าง",
      "cites": [
        "aaha-endocrine-b"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-docp",
      "type": "package-insert",
      "title": "Percorten-V / Zycortal (desoxycorticosterone pivalate) — veterinary label",
      "year": 2025,
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/desoxycorticosterone-docp-percorten-v-for-dogs-and-cats",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "aaha-endocrine-b",
      "type": "guideline",
      "title": "2023 AAHA Canine Hypoadrenocorticism Therapy Guidelines",
      "url": "https://www.aaha.org/resources/2023-aaha-selected-endocrinopathies-of-dogs-and-cats-guidelines/therapy-3/",
      "year": 2023,
      "note": "AAHA consensus guideline. Authoritative.",
      "cid": null
    },
    {
      "id": "paper-docp-lowdose",
      "type": "paper",
      "title": "Low-dose DOCP treatment of canine hypoadrenocorticism: a randomized controlled trial (Vincent 2021, JVIM)",
      "url": "https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.16195",
      "year": 2021,
      "note": "Peer-reviewed RCT supporting 1.1–1.5 mg/kg low-dose protocol.",
      "cid": null
    },
    {
      "id": "wikipedia-Desoxycortone",
      "type": "monograph",
      "title": "Desoxycorticosterone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Desoxycortone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H02AA03",
      "name": "Desoxycorticosterone (DOCP)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / AAHA + ACVIM guidelines / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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