Verify Dobutamine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "dobutamine",
  "nameEn": "Dobutamine",
  "nameTh": "โดบูทามีน",
  "class": "Emergency — β1-adrenergic inotrope (CRI)",
  "mechanism": "กระตุ้น β1-adrenergic receptor เป็นหลัก เพิ่มแรงบีบหัวใจ (inotropy) โดยมีผลต่ออัตราการเต้นและความดันน้อยกว่า dopamine; ให้แบบ CRI สำหรับภาวะหัวใจบีบตัวอ่อน",
  "brandNamesTh": [
    "Dobutrex"
  ],
  "indications": [
    {
      "text": "ภาวะหัวใจบีบตัวอ่อน (myocardial failure, cardiogenic shock) เพื่อเพิ่ม cardiac output; รองรับการไหลเวียนในภาวะวิกฤต; ให้แบบ CRI",
      "cites": [
        "merck-dobutamine",
        "tvp-cri-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ให้ทาง CRI ผ่าน infusion pump เท่านั้น; ระวัง arrhythmia (โดยเฉพาะแมวที่ไวกว่า — อาจชัก); ระวังใน HCM with outflow obstruction",
      "cites": [
        "merck-dobutamine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นเร็ว/arrhythmia, ในแมวอาจเกิดอาการชัก (seizure) ที่ขนาดสูง; ปรับขนาดอย่างระมัดระวัง",
      "cites": [
        "merck-dobutamine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Myocardial failure (CRI)",
      "route": "IV",
      "dose": "2–15 mcg/kg/min CRI ปรับตามการตอบสนอง",
      "cites": [
        "merck-dobutamine",
        "tvp-cri-b"
      ]
    },
    {
      "species": "feline",
      "indication": "Myocardial failure (CRI)",
      "route": "IV",
      "dose": "1–5 mcg/kg/min CRI (ขนาดต่ำกว่าสุนัข — เสี่ยงชัก)",
      "cites": [
        "merck-dobutamine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-dobutamine",
      "type": "textbook",
      "title": "Positive Inotropes — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/positive-inotropes-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tvp-cri-b",
      "type": "guideline",
      "title": "CRI use for anesthesia and analgesia — Today's Veterinary Practice",
      "url": "https://www.dvm360.com/view/cri-use-anesthesia-and-analgesia-proceedings",
      "year": 2024,
      "note": "Peer-reviewed veterinary clinical practice journal.",
      "cid": null
    },
    {
      "id": "wikipedia-Dobutamine",
      "type": "monograph",
      "title": "Dobutamine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Dobutamine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01CA07",
      "name": "Dobutamine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (RECOVER 2024 / BSAVA / Merck / AAHA / ACVIM / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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