Verify Diminazene aceturate

Drug JSON

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{
  "slug": "diminazene",
  "nameEn": "Diminazene aceturate",
  "nameTh": "ไดมินาซีน อะเซทูเรต",
  "class": "Antiprotozoal — aromatic diamidine (babesiosis/trypanosomiasis)",
  "mechanism": "aromatic diamidine ที่จับ DNA (kinetoplast/minor groove) ของโปรโตซัว ขัดขวางการจำลองสารพันธุกรรม ใช้รักษา babesiosis และ trypanosomiasis",
  "brandNamesTh": [
    "Berenil",
    "Ganaseg"
  ],
  "indications": [
    {
      "text": "การติดเชื้อ Babesia และ Trypanosoma ในสัตว์ (โค สุนัข) — โรคจากเห็บ/แมลงพาหะที่พบในเขตร้อน",
      "cites": [
        "paper-diminazene-babesiosis",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ช่วงความปลอดภัยแคบ (narrow margin) — ห้ามเกินขนาด; ระวังพิเศษในสุนัข (พิษระบบประสาทส่วนกลางจากการให้ขนาดสูง/ซ้ำ); เลี่ยงในอูฐและสัตว์บางชนิดที่ไวพิเศษ",
      "cites": [
        "paper-diminazene-babesiosis",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เจ็บ/บวมบริเวณฉีด, อาเจียน, อาการทางระบบประสาท (กล้ามเนื้อสั่น เดินเซ ชัก) และสมองส่วนลึกถูกทำลายเมื่อเกินขนาด — โดยเฉพาะในสุนัข",
      "cites": [
        "plumbs",
        "wikipedia-Diminazene"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Babesiosis",
      "route": "IM",
      "dose": "3.5 mg/kg IM ครั้งเดียว — ⚠️ ห้ามให้ซ้ำเกินขนาดเพราะเสี่ยงพิษระบบประสาท",
      "cites": [
        "plumbs",
        "paper-diminazene-babesiosis"
      ]
    },
    {
      "species": "bovine",
      "indication": "Babesiosis / trypanosomiasis",
      "route": "IM",
      "dose": "3.5 mg/kg IM (babesia) ถึง 7 mg/kg IM (trypanosome) ตามข้อบ่งใช้",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-QP51DF01",
      "type": "regulatory-database",
      "title": "WHO ATCvet Index — Diminazene (QP51DF01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QP51DF01&showdescription=no",
      "note": "WHO ATCvet (Q-code) classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "paper-diminazene-babesiosis",
      "type": "paper",
      "title": "Diminazene aceturate and imidocarb dipropionate-based combination therapy for babesiosis — a new paradigm",
      "year": 2023,
      "url": "https://pubmed.ncbi.nlm.nih.gov/36812788/",
      "note": "Peer-reviewed review of diminazene/imidocarb babesiosis therapy (Ticks Tick Borne Dis).",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Diminazene",
      "type": "monograph",
      "title": "Diminazene — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Diminazene",
      "note": "Tertiary cross-check for class + mechanism + ATCvet code. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATCvet Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QP51DF01",
      "name": "Diminazene",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATCvet / FDA label / Plumb’s / peer-reviewed), cross-checked. ATCvet code verified against WHO/Wikipedia. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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