Verify Diethylstilbestrol (DES)

Drug JSON

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{
  "slug": "diethylstilbestrol",
  "nameEn": "Diethylstilbestrol (DES)",
  "nameTh": "ไดเอทิลสติลเบสทรอล (DES)",
  "class": "Synthetic estrogen (estrogen-responsive incontinence)",
  "mechanism": "estrogen สังเคราะห์ที่เพิ่มความไวของ α-receptor และความตึงของหูรูดท่อปัสสาวะ ใช้รักษาภาวะปัสสาวะเล็ดที่ตอบสนองต่อ estrogen",
  "brandNamesTh": [
    "DES",
    "Stilbestrol"
  ],
  "indications": [
    {
      "text": "ภาวะปัสสาวะเล็ดที่ตอบสนองต่อ estrogen (estrogen-responsive urinary incontinence) ในสุนัขเพศเมียทำหมันแล้ว",
      "cites": [
        "dailymed-diethylstilbestrol",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามในสัตว์ตั้งท้อง; ระวังพิษไขกระดูกขึ้นกับขนาด (estrogen-induced bone marrow suppression) — ห้ามเกินขนาดและความถี่ที่กำหนดเด็ดขาด",
      "cites": [
        "dailymed-diethylstilbestrol",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "การกดไขกระดูก (thrombocytopenia/anemia/pancytopenia) เมื่อขนาดสูง/ใช้บ่อยเกิน, อาการของฮอร์โมนเพศ (vulvar swelling, attractiveness)",
      "cites": [
        "plumbs",
        "wikipedia-Diethylstilbestrol"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Estrogen-responsive incontinence",
      "route": "PO",
      "dose": "เริ่ม 0.1–1 mg ต่อตัว PO วันละครั้ง นาน 3–5 วัน แล้วลดเป็น ~1 mg ต่อตัว PO สัปดาห์ละครั้ง (ขนาดต่ำสุดที่คุมได้) — ⚠️ ห้ามเกินขนาด",
      "cites": [
        "plumbs",
        "dailymed-diethylstilbestrol"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-G03CB02",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Diethylstilbestrol (G03CB02)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=G03CB02&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical (incl. ATCvet Q-codes) classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-diethylstilbestrol",
      "type": "package-insert",
      "title": "Diethylstilbestrol — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=diethylstilbestrol",
      "note": "US FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled dose.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Diethylstilbestrol",
      "type": "monograph",
      "title": "Diethylstilbestrol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Diethylstilbestrol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "G03CB02",
      "name": "Diethylstilbestrol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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