Verify Detomidine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "detomidine",
  "nameEn": "Detomidine",
  "nameTh": "ดีโทมิดีน",
  "class": "α2-adrenergic agonist sedative (equine)",
  "mechanism": "กระตุ้น α2-adrenergic receptor ส่วนกลาง ทำให้สงบประสาท คลายกล้ามเนื้อ และระงับปวด ใช้เป็นยาสงบประสาทหลักในม้า (รูปฉีดและเจลใต้ลิ้น)",
  "brandNamesTh": [
    "Dormosedan"
  ],
  "indications": [
    {
      "text": "สงบประสาทและระงับปวดในม้าสำหรับการตรวจ/หัตถการแบบยืน (standing sedation) — มีรูปเจลใต้ลิ้น (Dormosedan Gel)",
      "cites": [
        "dailymed-detomidine",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "โรคหัวใจ/AV block, ภาวะช็อก, ม้าท้องระยะท้าย; ⚠️ ทำให้หัวใจเต้นช้า/AV block ชั่วคราว + ปัสสาวะมาก; กลับฤทธิ์ด้วย atipamezole/yohimbine",
      "cites": [
        "dailymed-detomidine",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นช้า, AV block, เหงื่อออก, ปัสสาวะมาก, เดินเซ; ก้มหัวต่ำ (ระวังบาดเจ็บ)",
      "cites": [
        "plumbs",
        "wikipedia-Detomidine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "equine",
      "indication": "Standing sedation / analgesia",
      "route": "IV",
      "dose": "0.01–0.04 mg/kg IV/IM (เริ่มต่ำ ปรับตามระดับความสงบ); เจลใต้ลิ้น 0.04 mg/kg",
      "cites": [
        "plumbs",
        "dailymed-detomidine"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-QN05CM90",
      "type": "regulatory-database",
      "title": "WHO ATC/ATCvet Index — Detomidine (QN05CM90)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QN05CM90&showdescription=no",
      "note": "WHO ATC/ATCvet classification. Code verified against Wikipedia drug infobox. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-detomidine",
      "type": "package-insert",
      "title": "Detomidine (Dormosedan) — DailyMed (FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=detomidine",
      "note": "FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Detomidine",
      "type": "monograph",
      "title": "Detomidine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Detomidine",
      "note": "Tertiary cross-check for class + mechanism + ATCvet code. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/ATCvet Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QN05CM90",
      "name": "Detomidine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATCvet / FDA label / Plumb’s / AAHA), cross-checked. ATCvet code verified against Wikipedia infobox. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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