Verify Desmopressin (DDAVP)

Drug JSON

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{
  "slug": "desmopressin",
  "nameEn": "Desmopressin (DDAVP)",
  "nameTh": "เดสโมเพรสซิน",
  "class": "Pituitary hormone — synthetic vasopressin analogue",
  "mechanism": "อนุพันธ์สังเคราะห์ของ vasopressin (ADH) ออกฤทธิ์ที่ V2 receptor ของไต เพิ่มการดูดน้ำกลับ ลดปริมาณปัสสาวะ; ใช้ทดแทนใน central diabetes insipidus",
  "brandNamesTh": [
    "DDAVP",
    "Minirin",
    "Stimate"
  ],
  "indications": [
    {
      "text": "central diabetes insipidus (พร่อง ADH) ในสุนัขและแมว; ใช้ในการวินิจฉัยแยกโรค (modified water deprivation/DDAVP trial); ช่วยภาวะเลือดออกบางชนิด (von Willebrand)",
      "cites": [
        "merck-di",
        "petplace-ddavp"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังภาวะน้ำเกิน/hyponatremia หากให้น้ำมากร่วมด้วย; ปรับขนาดตามการตอบสนอง (ปริมาณปัสสาวะ/ความถ่วงจำเพาะ)",
      "cites": [
        "merck-di"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พบน้อย: ระคายเคืองตา (รูปแบบหยอดตา/จมูก), hyponatremia หากใช้เกิน; โดยรวมปลอดภัย",
      "cites": [
        "merck-di"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Central diabetes insipidus",
      "route": "ocular",
      "dose": "1–2 หยด หยอดตา/จมูก ทุก 12 ชั่วโมง; หรือ 50–100 mcg PO ทุก 8–12 ชั่วโมง; SC 1–2 mcg/ตัว",
      "cites": [
        "merck-di",
        "petplace-ddavp"
      ]
    },
    {
      "species": "feline",
      "indication": "Central diabetes insipidus",
      "route": "ocular",
      "dose": "1–2 หยด หยอดตา/จมูก ทุก 12 ชั่วโมง; หรือ 50–100 mcg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "merck-di"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-di",
      "type": "textbook",
      "title": "Diabetes Insipidus in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/endocrine-system/the-pituitary-gland/diabetes-insipidus-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-ddavp",
      "type": "monograph",
      "title": "Desmopressin (DDAVP/Stimate) for Dogs and Cats — PetPlace",
      "year": 2025,
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/desmopressin-ddavp-stimate-for-dogs-and-cats",
      "note": "Clinical drug-library reference — DI dosing.",
      "cid": null
    },
    {
      "id": "wikipedia-Desmopressin",
      "type": "monograph",
      "title": "Desmopressin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Desmopressin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H01BA02",
      "name": "Desmopressin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (RECOVER 2024 / BSAVA / Merck / AAHA / ACVIM / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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