Verify Dantrolene

Drug JSON

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{
  "slug": "dantrolene",
  "nameEn": "Dantrolene",
  "nameTh": "แดนโทรลีน",
  "class": "Muscle relaxant — direct-acting (skeletal muscle)",
  "mechanism": "คลายกล้ามเนื้อลายโดยตรงที่ระดับ sarcoplasmic reticulum (ยับยั้งการปล่อย calcium ผ่าน ryanodine receptor) ลดการหดตัว; ใช้กับ functional urethral obstruction และ malignant hyperthermia",
  "brandNamesTh": [
    "Dantrium"
  ],
  "indications": [
    {
      "text": "functional urethral obstruction จาก external (striated) urethral sphincter tone สูง, malignant hyperthermia, และภาวะกล้ามเนื้อเกร็งจากพิษบางชนิด",
      "cites": [
        "petmd-dantrolene",
        "wedgewood-dantrolene"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ เป็นพิษต่อตับ (hepatotoxic) เมื่อใช้นาน/ขนาดสูง — ตรวจตับ; ระวังในโรคตับ; ทำให้กล้ามเนื้ออ่อนแรงทั่วไป",
      "cites": [
        "petmd-dantrolene"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กล้ามเนื้ออ่อนแรง, ง่วงซึม, ⚠️ hepatotoxicity (dose-related), GI upset",
      "cites": [
        "petmd-dantrolene"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Functional urethral obstruction (external sphincter)",
      "route": "PO",
      "dose": "0.5–2 mg/kg PO ทุก 8 ชั่วโมง",
      "cites": [
        "petmd-dantrolene",
        "wedgewood-dantrolene"
      ]
    },
    {
      "species": "feline",
      "indication": "Urethral spasm (external sphincter)",
      "route": "PO",
      "dose": "0.5–2 mg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "wedgewood-dantrolene"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าตับเป็นระยะเมื่อใช้นาน; หยุดยาหากเอนไซม์ตับสูง",
      "cites": [
        "petmd-dantrolene"
      ]
    }
  ],
  "citations": [
    {
      "id": "petmd-dantrolene",
      "type": "monograph",
      "title": "Dantrolene Sodium for Dogs, Cats, and Horses — PetMD",
      "url": "https://www.petmd.com/pet-medication/dantrolene-sodium",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wedgewood-dantrolene",
      "type": "guideline",
      "title": "Dantrolene Sodium veterinary dosing — Wedgewood",
      "url": "https://www.wedgewood.com/medications/dantrolene-sodium/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-dantrolene",
      "type": "monograph",
      "title": "Dantrolene — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Dantrolene",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "M03CA01",
      "name": "Dantrolene",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VSSO / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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