Verify Dacarbazine (DTIC)

Drug JSON

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{
  "slug": "dacarbazine",
  "nameEn": "Dacarbazine (DTIC)",
  "nameTh": "ดาคาร์บาซีน",
  "class": "Antineoplastic — triazene alkylating agent",
  "mechanism": "alkylating agent กลุ่ม triazene ต้องถูก activate ทาง metabolism สร้าง DNA methylation/cross-link; ใช้เป็น rescue agent ของ lymphoma และ sarcoma",
  "brandNamesTh": [
    "DTIC-Dome"
  ],
  "indications": [
    {
      "text": "lymphoma ที่กลับเป็นซ้ำ/ดื้อยา และ soft tissue sarcoma ในสุนัข — rescue agent (เดี่ยวหรือคู่ doxorubicin)",
      "cites": [
        "vsso-dacarbazine",
        "wikipedia-dacarbazine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; ⚠️ vesicant (extravasation = เนื้อตาย); กดไขกระดูก + GI toxicity รุนแรง; ปรับในตับ/ไตบกพร่อง; ให้ IV infusion ช้า",
      "cites": [
        "vsso-dacarbazine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, คลื่นไส้-อาเจียนรุนแรง, vesicant injury หากรั่ว, พิษตับ",
      "cites": [
        "vsso-dacarbazine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Rescue lymphoma / sarcoma — specialist",
      "route": "IV",
      "dose": "800–1000 mg/m² IV (infusion ช้า) ทุก 3 สัปดาห์ หรือ 200 mg/m²/วัน ติดต่อกัน 5 วัน ทุก 3 สัปดาห์ — ⚠️ oncology only",
      "notes": "ตรวจ CBC ก่อนทุกรอบ",
      "cites": [
        "vsso-dacarbazine"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ; ค่าตับ; ตรวจตำแหน่งให้ยา (vesicant)",
      "cites": [
        "vsso-dacarbazine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-dacarbazine",
      "type": "guideline",
      "title": "Dacarbazine (DTIC) chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "wikipedia-dacarbazine",
      "type": "monograph",
      "title": "Dacarbazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Dacarbazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01AX04",
      "name": "Dacarbazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / FDA labels / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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