Verify Cyclosporine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "cyclosporine",
  "nameEn": "Cyclosporine",
  "nameTh": "ไซโคลสปอริน",
  "class": "Immunomodulator — calcineurin inhibitor",
  "mechanism": "ยากดภูมิคุ้มกันกลุ่ม calcineurin inhibitor ยับยั้งการทำงานของ T-lymphocyte (ลดการสร้าง IL-2) จึงลดการตอบสนองภูมิคุ้มกัน; ใช้กับโรคภูมิแพ้ผิวหนังและโรคภูมิคุ้มกัน",
  "brandNamesTh": [
    "Atopica",
    "Optimmune (ocular)",
    "Neoral"
  ],
  "indications": [
    {
      "text": "atopic dermatitis ในสุนัข (Atopica) และโรคภูมิคุ้มกันต่าง ๆ (perianal fistula, IMHA adjunct); รูปแบบตา (Optimmune) สำหรับ KCS",
      "cites": [
        "fda-atopica"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังการติดเชื้อฉวยโอกาสและการเกิดเนื้องอกเมื่อกดภูมินาน; drug interaction ผ่าน CYP3A (ketoconazole เพิ่มระดับ); หลีกเลี่ยงในประวัติมะเร็ง",
      "cites": [
        "fda-atopica"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน ท้องเสีย (ช่วงแรก พบบ่อย), เหงือกหนา (gingival hyperplasia), papilloma, ขนขึ้นมาก (hypertrichosis); การติดเชื้อฉวยโอกาส",
      "cites": [
        "fda-atopica"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Atopic dermatitis",
      "route": "PO",
      "dose": "5 mg/kg PO วันละครั้ง นาน 30 วัน จากนั้นค่อย ๆ ลดความถี่ (วันเว้นวัน หรือ 2 ครั้ง/สัปดาห์)",
      "cites": [
        "fda-atopica"
      ]
    },
    {
      "species": "feline",
      "indication": "Atopic dermatitis (off-label)",
      "route": "PO",
      "dose": "7 mg/kg PO วันละครั้ง แล้วปรับลดความถี่",
      "cites": [
        "fda-atopica"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-atopica",
      "type": "package-insert",
      "title": "Atopica (cyclosporine) — FDA-approved veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/atopica.html",
      "note": "FDA veterinary label — canine atopic dermatitis 5 mg/kg/day + taper. Public FDA labeling.",
      "cid": null
    },
    {
      "id": "dailymed-cyclosporine",
      "type": "regulatory-database",
      "title": "Cyclosporine — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=cyclosporine",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "abf1e16953a0245b48cd9d9414d0dafe129e808934c0c28fee6df4ca71c45706"
    },
    {
      "id": "atc-L04AD01",
      "type": "guideline",
      "title": "ATC L04AD01 — Ciclosporin (Cyclosporine)",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=L04AD01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "86c2b8a9e9f7000116d36442504f6fef70c796c1cadd4e22b3c462ea15762d9d"
    },
    {
      "id": "pubchem-cyclosporine",
      "type": "monograph",
      "title": "Cyclosporine — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Cyclosporine",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "e20a151fdc14a7108be5a4ef4f732716a950fc96748231069053540e18ad4fce"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=cyclosporine",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=L04AD01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Cyclosporine",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "abf1e16953a0245b48cd9d9414d0dafe129e808934c0c28fee6df4ca71c45706",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "86c2b8a9e9f7000116d36442504f6fef70c796c1cadd4e22b3c462ea15762d9d",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "e20a151fdc14a7108be5a4ef4f732716a950fc96748231069053540e18ad4fce",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "L04AD01",
      "name": "Ciclosporin (Cyclosporine)",
      "level": 5
    },
    "rxnorm": {
      "cui": "3008",
      "name": "Cyclosporine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC L04AD01 + RxNorm 3008. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — cyclosporine 5 mg/kg/day + taper verified against FDA Atopica label. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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