Verify Cyclophosphamide

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "cyclophosphamide",
  "nameEn": "Cyclophosphamide",
  "nameTh": "ไซโคลฟอสฟาไมด์",
  "class": "Antineoplastic / immunosuppressant — alkylating agent (⚠️ hemorrhagic cystitis)",
  "mechanism": "ยา alkylating ชนิด nitrogen mustard prodrug (เปลี่ยนที่ตับ) เชื่อมขวาง DNA ยับยั้งการแบ่งเซลล์; ใช้ในเคมีบำบัด (CHOP lymphoma) และกดภูมิคุ้มกัน",
  "brandNamesTh": [
    "Cytoxan",
    "Endoxan"
  ],
  "indications": [
    {
      "text": "มะเร็งต่อมน้ำเหลือง (CHOP protocol), sarcoma, และโรคภูมิคุ้มกันบางชนิดในสุนัขและแมว — ยา oncology",
      "cites": [
        "petplace-cyclophosphamide",
        "merck-onco-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; ⚠️ sterile hemorrhagic cystitis จาก metabolite acrolein — ให้ตอนเช้าพร้อมขับปัสสาวะ (diuresis), ส่งเสริมการดื่มน้ำ; กดไขกระดูก; ห้ามในการติดเชื้อทางเดินปัสสาวะ active",
      "cites": [
        "petplace-cyclophosphamide",
        "merck-onco-b"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (neutropenia), GI upset, ⚠️ hemorrhagic cystitis (ปัสสาวะเป็นเลือด เบ่งปัสสาวะ), ผมร่วงในบางพันธุ์; เฝ้าระวัง CBC + urinalysis",
      "cites": [
        "petplace-cyclophosphamide"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lymphoma (CHOP) / immune-mediated (specialist)",
      "route": "PO",
      "dose": "50 mg/m² PO วันละครั้ง แบบ 4 วันให้-3 วันหยุด หรือ 200–250 mg/m² ในรอบ CHOP — ⚠️ oncology only",
      "notes": "ให้ตอนเช้า + ส่งเสริม diuresis เพื่อกัน hemorrhagic cystitis; ตรวจ CBC ก่อนทุกรอบ",
      "cites": [
        "petplace-cyclophosphamide",
        "merck-onco-b"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ (nadir); urinalysis เฝ้าระวัง hemorrhagic cystitis; หยุดยาหากพบปัสสาวะเป็นเลือด",
      "cites": [
        "merck-onco-b"
      ]
    }
  ],
  "citations": [
    {
      "id": "petplace-cyclophosphamide",
      "type": "monograph",
      "title": "Cyclophosphamide for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/cyclophosphamide-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-onco-b",
      "type": "textbook",
      "title": "Antineoplastic Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antineoplastic-agents/antineoplastic-agents-introduction",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-cyclophosphamide",
      "type": "monograph",
      "title": "Cyclophosphamide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Cyclophosphamide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01AA01",
      "name": "Cyclophosphamide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VIN / PetPlace / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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