Verify Clomipramine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "clomipramine",
  "nameEn": "Clomipramine",
  "nameTh": "โคลมิพรามีน",
  "class": "Behavioral — tricyclic antidepressant (TCA)",
  "mechanism": "ยา tricyclic antidepressant ยับยั้งการเก็บกลับ serotonin และ norepinephrine; ใช้รักษาปัญหาพฤติกรรม โดยเฉพาะ separation anxiety และ compulsive disorder ออกฤทธิ์เต็มที่ต้องใช้หลายสัปดาห์",
  "brandNamesTh": [
    "Clomicalm"
  ],
  "indications": [
    {
      "text": "รักษา separation anxiety ในสุนัข (Clomicalm ได้รับการรับรอง FDA) และ compulsive/anxiety disorder; ในแมวใช้กับ urine marking และความวิตกกังวล — ใช้ร่วมกับ behavior modification",
      "cites": [
        "merck-behavior",
        "petmd-clomipramine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ร่วม MAOI หรือยา serotonergic อื่น (เสี่ยง serotonin syndrome); ระวังในโรคหัวใจ (arrhythmia), ต้อหิน, ปัสสาวะคั่ง, ตับบกพร่อง",
      "cites": [
        "merck-behavior"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม, ปากแห้ง, ปัสสาวะคั่ง, อาเจียน; ฤทธิ์ anticholinergic + อาจกระทบการนำไฟฟ้าหัวใจที่ขนาดสูง",
      "cites": [
        "petmd-clomipramine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Separation anxiety / compulsive disorder",
      "route": "PO",
      "dose": "1–2 mg/kg PO ทุก 12 ชั่วโมง (รวม 1–3 mg/kg/วัน)",
      "cites": [
        "merck-behavior",
        "petmd-clomipramine"
      ]
    },
    {
      "species": "feline",
      "indication": "Urine marking / anxiety",
      "route": "PO",
      "dose": "0.25–0.5 mg/kg PO วันละครั้ง",
      "cites": [
        "petmd-clomipramine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-behavior",
      "type": "textbook",
      "title": "Behavioral Pharmacology — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/behavior/behavioral-medicine-introduction/drugs-and-behavior",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petmd-clomipramine",
      "type": "monograph",
      "title": "Clomipramine (Clomicalm) for Dogs and Cats — PetPlace",
      "year": 2025,
      "url": "https://www.petmd.com/pharmacy/clomipramine-clomicalm-dogs-cats",
      "note": "Clinical drug-library reference.",
      "cid": null
    },
    {
      "id": "wikipedia-clomipramine",
      "type": "monograph",
      "title": "Clomipramine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Clomipramine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N06AA04",
      "name": "Clomipramine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / VSSO chemo protocols / FDA-EMA labels / Today's Vet Practice), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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