Verify Clemastine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "clemastine",
  "nameEn": "Clemastine",
  "nameTh": "เคลมาสทีน",
  "class": "Antihistamine — first-generation H1 antagonist",
  "mechanism": "ยาแก้แพ้รุ่นแรก (first-generation H1 antagonist) ปิดกั้น histamine H1 receptor ลดอาการคัน/แพ้; ผ่าน blood-brain barrier จึงทำให้ง่วง",
  "brandNamesTh": [
    "Tavist",
    "Tavegyl"
  ],
  "indications": [
    {
      "text": "อาการแพ้และคัน (allergic dermatitis, atopy adjunct), ลมพิษ, ป้องกันปฏิกิริยาแพ้ ในสุนัขและแมว (ผลในสุนัขผันแปรเพราะการดูดซึมทางปากต่ำ)",
      "cites": [
        "merck-antihistamine-h",
        "plumbs-clemastine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในต้อหิน, ปัสสาวะคั่ง, ทางเดินอาหารอุดตัน (ฤทธิ์ anticholinergic); ทำให้ง่วง; bioavailability ทางปากในสุนัขต่ำ-ผันแปร",
      "cites": [
        "plumbs-clemastine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม, ปากแห้ง, ปัสสาวะคั่ง, ท้องผูก; บางตัวกระสับกระส่าย",
      "cites": [
        "merck-antihistamine-h"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Allergic pruritus",
      "route": "PO",
      "dose": "0.05–0.1 mg/kg PO ทุก 12 ชั่วโมง",
      "cites": [
        "merck-antihistamine-h",
        "plumbs-clemastine"
      ]
    },
    {
      "species": "feline",
      "indication": "Allergic pruritus",
      "route": "PO",
      "dose": "0.15 mg/kg (≈ 0.34–0.68 mg/ตัว) PO ทุก 12 ชั่วโมง",
      "cites": [
        "plumbs-clemastine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antihistamine-h",
      "type": "textbook",
      "title": "Antihistamines — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-respiratory-system/antihistamines-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "plumbs-clemastine",
      "type": "guideline",
      "title": "Clemastine fumarate veterinary dosing — Plumb's / Wedgewood",
      "url": "https://www.wedgewood.com/medications/clemastine-fumarate/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-clemastine",
      "type": "monograph",
      "title": "Clemastine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Clemastine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "R06AA04",
      "name": "Clemastine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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