Verify Clarithromycin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "clarithromycin",
  "nameEn": "Clarithromycin",
  "nameTh": "คลาริโทรมัยซิน",
  "class": "Antibiotic — macrolide",
  "mechanism": "macrolide — จับ 50S ribosome ยับยั้งการสร้างโปรตีนแบคทีเรีย (bacteriostatic); ซึมเข้าเนื้อเยื่อ/intracellular ดี ใช้กับเชื้อในเซลล์และ atypical",
  "brandNamesTh": [
    "Klacid",
    "Biaxin"
  ],
  "indications": [
    {
      "text": "ติดเชื้อในเซลล์/atypical (เช่น Mycobacterium, Rhodococcus equi ในลูกม้า — มักคู่ rifampin), ติดเชื้อผิวหนัง/ทางเดินหายใจที่ไวต่อยา ในสุนัขและแมว (off-label — ไม่มีทะเบียนสัตว์)",
      "cites": [
        "merck-macrolide",
        "aavpt-macrolide"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามในสัตว์แพ้ macrolide; ⚠️ ยับยั้ง CYP3A — เพิ่มระดับยาหลายชนิด (cisapride, cyclosporine ฯลฯ); GI upset; ปรับในตับ/ไตบกพร่อง; off-label",
      "cites": [
        "merck-macrolide"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset (อาเจียน ท้องเสีย เบื่ออาหาร), drug interactions (CYP3A), ตับเอนไซม์สูงบางตัว",
      "cites": [
        "merck-macrolide"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Susceptible / intracellular infection",
      "route": "PO",
      "dose": "7.5 mg/kg PO ทุก 12 ชั่วโมง (off-label)",
      "cites": [
        "merck-macrolide",
        "aavpt-macrolide"
      ]
    },
    {
      "species": "feline",
      "indication": "Susceptible infection (incl. mycobacterial — combo)",
      "route": "PO",
      "dose": "7.5 mg/kg PO ทุก 12 ชั่วโมง (มักอยู่ในสูตรหลายยาสำหรับ mycobacteria)",
      "cites": [
        "aavpt-macrolide"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-macrolide",
      "type": "textbook",
      "title": "Macrolide Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/macrolide-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "aavpt-macrolide",
      "type": "guideline",
      "title": "Macrolides (Veterinary—Systemic) — AAVPT monograph",
      "url": "https://cdn.ymaws.com/www.aavpt.org/resource/resmgr/imported/macrolides.pdf",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-clarithromycin",
      "type": "monograph",
      "title": "Clarithromycin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Clarithromycin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01FA09",
      "name": "Clarithromycin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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