Verify Cisplatin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "cisplatin",
  "nameEn": "Cisplatin",
  "nameTh": "ซิสพลาติน",
  "class": "Antineoplastic — platinum alkylating-like agent",
  "mechanism": "สร้าง DNA cross-link ขัดขวางการจำลองและถอดรหัส DNA ของเซลล์มะเร็ง ใช้รักษามะเร็งหลายชนิด (osteosarcoma, carcinoma) ในสุนัข",
  "brandNamesTh": [
    "Platinol"
  ],
  "indications": [
    {
      "text": "มะเร็งกระดูก (osteosarcoma), carcinoma หลายชนิด, mesothelioma ในสุนัข — ให้พร้อม saline diuresis ป้องกันพิษไต",
      "cites": [
        "vsso",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️⚠️ ห้ามใช้ในแมวโดยเด็ดขาด (ทำให้เกิด pulmonary edema ถึงตาย); โรคไตบกพร่อง; ต้องทำ forced diuresis เสมอในสุนัข",
      "cites": [
        "vsso",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พิษไตรุนแรง (ต้อง diuresis), อาเจียนรุนแรง, กดไขกระดูก, พิษหู; ⚠️ ปอดบวมน้ำถึงตายในแมว",
      "cites": [
        "plumbs",
        "wikipedia-Cisplatin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Osteosarcoma / carcinoma",
      "route": "IV",
      "dose": "60–70 mg/m² IV ทุก 3 สัปดาห์ พร้อม saline diuresis + ยาแก้อาเจียน (ตามโปรโตคอลมะเร็ง)",
      "cites": [
        "vsso",
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-L01XA01",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Cisplatin (L01XA01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=L01XA01&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "vsso",
      "type": "guideline",
      "title": "VSSO — Veterinary Society of Surgical Oncology chemotherapy protocols",
      "year": 2026,
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "note": "Veterinary oncology dosing reference for cytotoxic protocols.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Cisplatin",
      "type": "monograph",
      "title": "Cisplatin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Cisplatin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01XA01",
      "name": "Cisplatin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / VSSO), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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