Verify Chlorpromazine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "chlorpromazine",
  "nameEn": "Chlorpromazine",
  "nameTh": "คลอร์โพรมาซีน",
  "class": "Anti-emetic — phenothiazine tranquilizer (antiemetic + sedative)",
  "mechanism": "phenothiazine (aliphatic) — ปิดกั้น dopamine D2 receptor ที่ chemoreceptor trigger zone ระงับอาเจียนกว้าง + ฤทธิ์สงบประสาท/antihistamine; กลุ่มเดียวกับ acepromazine/prochlorperazine",
  "brandNamesTh": [
    "Thorazine",
    "Largactil"
  ],
  "indications": [
    {
      "text": "อาเจียน/คลื่นไส้ที่ดื้อยาในสุนัขและแมว (broad-spectrum antiemetic), สงบประสาท; ⚠️ maropitant/ondansetron เป็นทางเลือกแรกกว่า (efficacy สูงกว่าใน chemo-induced)",
      "cites": [
        "merck-emesis-t",
        "dvm360-antiemetic-t"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวัง hypotension (alpha-block เด่น — ห้าม/ระวังในภาวะขาดน้ำ-ช็อก), sedation, extrapyramidal signs; ลด seizure threshold (ระวังในสัตว์ชัก); ห้ามให้ร่วม organophosphate",
      "cites": [
        "merck-emesis-t",
        "dvm360-antiemetic-t"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ (เด่น), ซึมลึก, extrapyramidal (rigidity/tremor), ลด seizure threshold",
      "cites": [
        "dvm360-antiemetic-t"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Refractory vomiting / nausea",
      "route": "SC",
      "dose": "0.5 mg/kg SC/IM ทุก 6–8 ชั่วโมง",
      "cites": [
        "merck-emesis-t",
        "dvm360-antiemetic-t"
      ]
    },
    {
      "species": "feline",
      "indication": "Refractory vomiting / nausea",
      "route": "SC",
      "dose": "0.5 mg/kg SC/IM ทุก 6–8 ชั่วโมง",
      "cites": [
        "dvm360-antiemetic-t"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-emesis-t",
      "type": "textbook",
      "title": "Drugs Used to Control or Stimulate Vomiting in Monogastric Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-used-to-control-or-stimulate-vomiting-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dvm360-antiemetic-t",
      "type": "guideline",
      "title": "Antiemetic therapy (chlorpromazine phenothiazine) — dvm360",
      "url": "https://www.dvm360.com/view/antiemetic-therapy-proceedings",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-chlorpromazine",
      "type": "monograph",
      "title": "Chlorpromazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Chlorpromazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N05AA01",
      "name": "Chlorpromazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / VCA / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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