Verify Chloramphenicol

Drug JSON

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{
  "slug": "chloramphenicol",
  "nameEn": "Chloramphenicol",
  "nameTh": "คลอแรมเฟนิคอล",
  "class": "Antibiotic — amphenicol (broad-spectrum, ⚠️ human aplastic anemia risk)",
  "mechanism": "ยาปฏิชีวนะกลุ่ม amphenicol จับ 50S ribosome ยับยั้งการสร้างโปรตีนแบคทีเรีย; ออกฤทธิ์ bacteriostatic วงกว้าง ซึมเข้าเนื้อเยื่อ/CNS/ตา/prostate ได้ดี; ใช้กับเชื้อดื้อยา (รวม MRSP)",
  "brandNamesTh": [
    "Chloromycetin"
  ],
  "indications": [
    {
      "text": "ติดเชื้อแบคทีเรียดื้อยา (รวม methicillin-resistant Staphylococcus pseudintermedius), การติดเชื้อที่ต้องการการซึมเข้าเนื้อเยื่อลึก (CNS, ตา, ต่อมลูกหมาก, กระดูก)",
      "cites": [
        "merck-amphenicol",
        "vin-chloramphenicol"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ความเสี่ยงต่อคน: ทำให้เกิด aplastic anemia ที่อาจถึงชีวิตในมนุษย์ — เจ้าของต้องสวมถุงมือและหลีกเลี่ยงการสัมผัส; ปรับลดในตับบกพร่อง; ระวังในลูกสัตว์",
      "cites": [
        "vin-chloramphenicol"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูกแบบ reversible (สัตว์), GI upset, เบื่ออาหาร; ในแมวขนาดสูง/นานเสี่ยงกดไขกระดูกมากกว่า; ⚠️ ในสุนัขใหญ่อาจเกิดอ่อนแรงขาหลัง",
      "cites": [
        "merck-amphenicol",
        "vin-chloramphenicol"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Resistant bacterial infection",
      "route": "PO",
      "dose": "40–50 mg/kg PO ทุก 8 ชั่วโมง",
      "cites": [
        "vin-chloramphenicol",
        "merck-amphenicol"
      ]
    },
    {
      "species": "feline",
      "indication": "Resistant bacterial infection",
      "route": "PO",
      "dose": "12.5–20 mg/kg PO ทุก 12 ชั่วโมง",
      "cites": [
        "vin-chloramphenicol"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-amphenicol",
      "type": "textbook",
      "title": "Amphenicols (Chloramphenicol, Florfenicol) — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/chloramphenicol-and-derivatives",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vin-chloramphenicol",
      "type": "guideline",
      "title": "Chloramphenicol Use in Dogs and Cats — Veterinary Partner (VIN)",
      "year": 2024,
      "url": "https://veterinarypartner.vin.com/doc/?id=4951497&pid=19239",
      "note": "VIN clinical reference — dog 40–50 mg/kg q8h, cat 12.5–20 mg/kg q12h, human aplastic-anemia handling warning.",
      "cid": null
    },
    {
      "id": "wikipedia-chloramphenicol",
      "type": "monograph",
      "title": "Chloramphenicol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Chloramphenicol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01BA01",
      "name": "Chloramphenicol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / VSSO chemo protocols / FDA-EMA labels / Today's Vet Practice), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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