Verify Ceftriaxone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "ceftriaxone",
  "nameEn": "Ceftriaxone",
  "nameTh": "เซฟไตรอะโซน",
  "class": "Antibiotic — third-generation cephalosporin",
  "mechanism": "cephalosporin รุ่นที่ 3 ยับยั้งการสร้างผนังเซลล์ (bind PBP); สเปกตรัม gram-negative กว้าง + ซึมเข้า CSF ได้ดี; ครึ่งชีวิตยาวให้วันละครั้งได้ (รูปฉีด)",
  "brandNamesTh": [
    "Rocephin"
  ],
  "indications": [
    {
      "text": "ติดเชื้อ gram-negative รุนแรง, ติดเชื้อระบบประสาท (meningitis — ซึมเข้า CSF), sepsis, และเชื้อไวต่อยาที่ต้องการ third-gen ในสุนัขและแมว (รูปฉีด)",
      "cites": [
        "merck-cephalosporins-j",
        "petplace-ceftriaxone"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามในสัตว์แพ้ cephalosporin/penicillin; ห้ามผสมสารละลายมีแคลเซียม (ตกตะกอน); ปรับในไต/ตับบกพร่อง; ระวังในตั้งท้อง; ใช้อย่างสมเหตุผล (antimicrobial stewardship — เป็น critically important antimicrobial)",
      "cites": [
        "merck-cephalosporins-j",
        "petplace-ceftriaxone"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset, แพ้ยา, ปวดจุดฉีด IM, เปลี่ยน gut flora; ตกตะกอนกับแคลเซียม",
      "cites": [
        "petplace-ceftriaxone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Susceptible gram-negative / CNS infection",
      "route": "IV",
      "dose": "20–50 mg/kg IV/IM วันละครั้ง (เคสรุนแรง q12h)",
      "cites": [
        "petplace-ceftriaxone"
      ]
    },
    {
      "species": "feline",
      "indication": "Susceptible serious infection",
      "route": "IV",
      "dose": "25–50 mg/kg IV/IM ทุก 12–24 ชั่วโมง",
      "cites": [
        "petplace-ceftriaxone"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-cephalosporins-j",
      "type": "textbook",
      "title": "Cephalosporins — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/cephalosporins",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-ceftriaxone",
      "type": "monograph",
      "title": "Ceftriaxone (Rocephin) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/ceftriaxone-rocephin-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-ceftriaxone",
      "type": "monograph",
      "title": "Ceftriaxone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Ceftriaxone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01DD04",
      "name": "Ceftriaxone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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