Verify Carboplatin

Drug JSON

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{
  "slug": "carboplatin",
  "nameEn": "Carboplatin",
  "nameTh": "คาร์โบพลาติน",
  "class": "Antineoplastic — platinum alkylating-like agent (osteosarcoma)",
  "mechanism": "สารประกอบ platinum สร้าง DNA cross-link (intra/inter-strand) ยับยั้งการจำลอง DNA; เป็นยาหลักของ canine osteosarcoma หลังตัดขา; พิษไตน้อยกว่า cisplatin จึงนิยมในสัตว์เล็ก",
  "brandNamesTh": [
    "Paraplatin"
  ],
  "indications": [
    {
      "text": "osteosarcoma (หลังตัดขา — adjuvant), carcinoma หลายชนิด, melanoma, mesothelioma ในสุนัขและแมว — ยา oncology หลัก",
      "cites": [
        "vsso-carboplatin",
        "paper-carbo-osa"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; กดไขกระดูก (nadir thrombocytopenia/neutropenia); ⚠️ vesicant; ปรับขนาดตาม GFR ในไตบกพร่อง (ขับทางไต)",
      "cites": [
        "vsso-carboplatin",
        "paper-carbo-osa"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (โดยเฉพาะ thrombocytopenia — dose-limiting), GI upset; พิษไตน้อยกว่า cisplatin; ในแมวต้องระวัง prolonged myelosuppression",
      "cites": [
        "vsso-carboplatin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Osteosarcoma (adjuvant) / carcinoma — specialist",
      "route": "IV",
      "dose": "300 mg/m² IV ทุก 21 วัน รวม 4–6 โดส — ⚠️ oncology only, ผ่านสาย IV ที่แน่นอน",
      "notes": "ตรวจ CBC ก่อนทุกรอบ; ปรับตาม GFR",
      "cites": [
        "vsso-carboplatin",
        "paper-carbo-osa"
      ]
    },
    {
      "species": "feline",
      "indication": "Carcinoma / sarcoma — specialist",
      "route": "IV",
      "dose": "200–240 mg/m² IV ทุก 3–4 สัปดาห์ — ⚠️ oncology only; เฝ้าระวัง myelosuppression นาน",
      "cites": [
        "vsso-carboplatin"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ (platelet nadir ~14 วัน); ค่าไต/GFR; ปรับขนาดตามผล",
      "cites": [
        "vsso-carboplatin"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-carboplatin",
      "type": "guideline",
      "title": "Carboplatin chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "paper-carbo-osa",
      "type": "paper",
      "title": "Carboplatin vs doxorubicin chemotherapy for canine appendicular osteosarcoma (470 dogs, JVIM)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4857984/",
      "year": 2023,
      "note": "Peer-reviewed canine OSA outcome study — 300 mg/m² q21d.",
      "cid": null
    },
    {
      "id": "wikipedia-carboplatin",
      "type": "monograph",
      "title": "Carboplatin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Carboplatin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01XA02",
      "name": "Carboplatin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VSSO / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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