Verify Atropine (ophthalmic)

Drug JSON

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{
  "slug": "atropine-ophthalmic",
  "nameEn": "Atropine (ophthalmic)",
  "nameTh": "อะโทรพีน (ยาหยอดตา)",
  "class": "Ophthalmic anticholinergic — mydriatic / cycloplegic",
  "mechanism": "ปิดกั้น muscarinic receptor ของกล้ามเนื้อ iris/ciliary ทำให้รูม่านตาขยายและกล้ามเนื้อ ciliary คลายตัว ลดอาการปวดจาก ciliary spasm ในม่านตาอักเสบ",
  "brandNamesTh": [
    "Atropine eye"
  ],
  "indications": [
    {
      "text": "ม่านตาอักเสบ (anterior uveitis) เพื่อลดปวดจาก ciliary spasm และป้องกัน synechiae; ขยายรูม่านตาเพื่อตรวจ/ผ่าตัด",
      "cites": [
        "dailymed-atropine ophthalmic",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามใช้ในต้อหิน (glaucoma — เพิ่มความดันลูกตา); ลดการสร้างน้ำตา (ระวังตาแห้ง); ⚠️ แมวอาจน้ำลายไหลจากรสขม — แนะนำรูป ointment ในแมว",
      "cites": [
        "dailymed-atropine ophthalmic",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "รูม่านตาขยายนาน (ไวแสง), น้ำตาลด, น้ำลายไหลในแมว, ความดันลูกตาสูงขึ้นในสัตว์เสี่ยงต้อหิน",
      "cites": [
        "plumbs",
        "wikipedia-Atropine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anterior uveitis (cycloplegia/mydriasis)",
      "route": "ocular",
      "dose": "หยอด/ป้ายตา 1% ทุก 8–24 ชั่วโมง จนรูม่านตาขยาย (to effect) แล้วลดความถี่",
      "cites": [
        "plumbs",
        "dailymed-atropine ophthalmic"
      ]
    },
    {
      "species": "feline",
      "indication": "Anterior uveitis (cycloplegia/mydriasis)",
      "route": "ocular",
      "dose": "ป้ายตา ointment 1% ทุก 12–24 ชั่วโมง (เลี่ยงสารละลายเพื่อลดการกลืน/น้ำลายไหล)",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-S01FA01",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Atropine (ophthalmic) (S01FA01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=S01FA01&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-atropine ophthalmic",
      "type": "package-insert",
      "title": "Atropine ophthalmic — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=atropine%20ophthalmic",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Atropine",
      "type": "monograph",
      "title": "Atropine (ophthalmic) — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Atropine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "S01FA01",
      "name": "Atropine (ophthalmic)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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