Verify Atipamezole

Drug JSON

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{
  "slug": "atipamezole",
  "nameEn": "Atipamezole",
  "nameTh": "อะติพาเมโซล",
  "class": "Antidote — alpha-2 adrenergic antagonist (reversal agent, veterinary)",
  "mechanism": "alpha-2 adrenergic antagonist (Antisedan) แย่งจับ alpha-2 receptor จึงกลับฤทธิ์สงบ ระงับปวด และผลต่อหัวใจ/หลอดเลือดของ dexmedetomidine/medetomidine; เป็นยาสำหรับสัตว์โดยเฉพาะ",
  "brandNamesTh": [
    "Antisedan",
    "Atipam"
  ],
  "indications": [
    {
      "text": "กลับฤทธิ์ alpha-2 agonist (dexmedetomidine, medetomidine) เพื่อให้สัตว์ฟื้นเร็วหลังสงบประสาท/วางยา",
      "cites": [
        "fda-antisedan",
        "cliniciansbrief-atipamezole"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "การกลับฤทธิ์เฉียบพลันทำให้ตื่นเต้น หัวใจเต้นเร็ว และความดันเปลี่ยน; ฉีด IV เร็วเสี่ยงต่อภาวะหัวใจและหลอดเลือด — แนะนำ IM",
      "cites": [
        "fda-antisedan"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ตื่นเต้น/กระสับกระส่าย, หัวใจเต้นเร็ว, น้ำลายไหล, อาเจียน, ตัวสั่น; ฤทธิ์ระงับปวดของ alpha-2 หายไปด้วย",
      "cites": [
        "fda-antisedan"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Alpha-2 (dexmedetomidine) reversal",
      "route": "IM",
      "dose": "0.1–0.3 mg/kg IM (โดยทั่วไปให้ปริมาตรเท่ากับ dexmedetomidine ที่ใช้)",
      "cites": [
        "cliniciansbrief-atipamezole",
        "fda-antisedan"
      ]
    },
    {
      "species": "feline",
      "indication": "Alpha-2 reversal",
      "route": "IM",
      "dose": "0.1–0.3 mg/kg IM ตามปริมาตร dexmedetomidine ที่ให้",
      "cites": [
        "cliniciansbrief-atipamezole",
        "fda-antisedan"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-antisedan",
      "type": "package-insert",
      "title": "Antisedan (atipamezole HCl) — FDA NADA 141-033",
      "year": 2025,
      "url": "https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/563",
      "note": "FDA veterinary label — alpha-2 reversal dosing. Public FDA labeling.",
      "cid": null
    },
    {
      "id": "cliniciansbrief-atipamezole",
      "type": "guideline",
      "title": "Dexmedetomidine & Atipamezole Uses, Dosing in Dogs & Cats — Clinician’s Brief",
      "year": 2024,
      "url": "https://www.cliniciansbrief.com/article/dexmedetomidine-atipamezole",
      "note": "Peer-reviewed clinical reference — atipamezole 0.1–0.3 mg/kg IM reversal. Secondary reference.",
      "cid": null
    },
    {
      "id": "dailymed-atipamezole",
      "type": "regulatory-database",
      "title": "Atipamezole — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=atipamezole",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "a5e30b95ecaac4c5dfdaf949fe1760247adfd4c5f4a4572d696955edfa9f8af7"
    },
    {
      "id": "atc-QV03AB94",
      "type": "guideline",
      "title": "ATC QV03AB94 — Atipamezole (veterinary, α2-antagonist reversal)",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QV03AB94&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "c797470f2d883b5be77f108f147ceaccabb307a28ac5e359da4fe18daee9a1f2"
    },
    {
      "id": "pubchem-atipamezole",
      "type": "monograph",
      "title": "Atipamezole — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Atipamezole",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "566bcf209229878949fd022829c2dd579abf771da4e06f5a3259f3208bf405af"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=atipamezole",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=QV03AB94&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Atipamezole",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "a5e30b95ecaac4c5dfdaf949fe1760247adfd4c5f4a4572d696955edfa9f8af7",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "c797470f2d883b5be77f108f147ceaccabb307a28ac5e359da4fe18daee9a1f2",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "566bcf209229878949fd022829c2dd579abf771da4e06f5a3259f3208bf405af",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "QV03AB94",
      "name": "Atipamezole (veterinary, α2-antagonist reversal)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC QV03AB94 (vet-only, no human RxNorm CUI). Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — atipamezole 0.1–0.3 mg/kg IM (volume-matched to dexmedetomidine) verified against FDA Antisedan label + Clinician’s Brief. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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