Verify L-asparaginase

Drug JSON

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{
  "slug": "asparaginase",
  "nameEn": "L-asparaginase",
  "nameTh": "แอลแอสพาราจิเนส",
  "class": "Antineoplastic — enzyme (asparagine depletion)",
  "mechanism": "เอนไซม์ที่สลาย asparagine ในเลือด ทำให้เซลล์มะเร็ง lymphoid (ซึ่งสร้าง asparagine เองไม่ได้) ขาดกรดอะมิโนที่จำเป็นต่อการสร้างโปรตีน → apoptosis; เป็นยาหลักของ lymphoma",
  "brandNamesTh": [
    "Elspar",
    "L-ASP"
  ],
  "indications": [
    {
      "text": "lymphoma และ lymphoid leukemia ในสุนัขและแมว — ทั้ง naïve และ relapse, มักอยู่ในโปรโตคอลหลายยา (เช่น CHOP, L-CHOP)",
      "cites": [
        "vsso-asparaginase",
        "cb-lymphoma"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; ⚠️ ห้ามให้ IV (เสี่ยง anaphylaxis สูง — ให้ IM/SC เท่านั้น); ⚠️ pre-treat ด้วย diphenhydramine (สุนัข 2 mg/kg, แมว 1 mg/kg) ก่อน 20–30 นาทีในโดสถัด ๆ ไป; ระวัง pancreatitis + coagulopathy",
      "cites": [
        "vsso-asparaginase",
        "cb-lymphoma"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ปฏิกิริยาแพ้/anaphylaxis (โดยเฉพาะให้ซ้ำ), pancreatitis, ความผิดปกติการแข็งตัวของเลือด, GI upset; กดไขกระดูกน้อย",
      "cites": [
        "cb-lymphoma"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lymphoma — specialist",
      "route": "IM",
      "dose": "400 IU/kg หรือ 10,000 IU/m² IM/SC สัปดาห์ละครั้ง 2–4 ครั้ง (สูงสุด 10,000 IU/ตัว) — ⚠️ ห้าม IV, pre-treat antihistamine",
      "cites": [
        "vsso-asparaginase",
        "cb-lymphoma"
      ]
    },
    {
      "species": "feline",
      "indication": "Lymphoma — specialist",
      "route": "IM",
      "dose": "400 IU/kg IM/SC สัปดาห์ละครั้ง 2–4 ครั้ง — ⚠️ ห้าม IV",
      "cites": [
        "vsso-asparaginase"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-asparaginase",
      "type": "guideline",
      "title": "L-asparaginase chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "cb-lymphoma",
      "type": "guideline",
      "title": "Which Drugs Are Used for Medical Management of Lymphoma in Dogs & Cats — Clinician's Brief",
      "url": "https://www.cliniciansbrief.com/article/which-drugs-are-used-medical-management-lymphoma-dogs-cats-part-1",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-asparaginase",
      "type": "monograph",
      "title": "Asparaginase — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Asparaginase",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01XX02",
      "name": "Asparaginase",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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