Verify Ampicillin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "ampicillin",
  "nameEn": "Ampicillin",
  "nameTh": "แอมพิซิลลิน",
  "class": "Antibiotic — aminopenicillin (beta-lactam)",
  "mechanism": "aminopenicillin ออกฤทธิ์ฆ่าเชื้อโดยยับยั้งการสร้างผนังเซลล์แบคทีเรีย (bind penicillin-binding proteins); ครอบคลุมกว้างกว่า penicillin G เล็กน้อย (รวม gram-negative บางชนิด) แต่ถูก beta-lactamase ทำลายได้",
  "brandNamesTh": [
    "Polyflex",
    "Ampicillin sodium"
  ],
  "indications": [
    {
      "text": "ติดเชื้อแบคทีเรียที่ไวต่อยา (ทางเดินปัสสาวะ ผิวหนัง ทางเดินหายใจ leptospirosis); รูปฉีดนิยมกว่ารูปกินเพราะการดูดซึมทางปากต่ำ (amoxicillin ดูดซึมดีกว่าสำหรับ PO)",
      "cites": [
        "merck-penicillins-h",
        "vca-ampicillin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ในสัตว์แพ้ penicillin/cephalosporin; ปรับขนาดในไตบกพร่อง; ลด efficacy ต่อเชื้อที่สร้าง beta-lactamase (ใช้ amoxicillin-clavulanate แทน)",
      "cites": [
        "merck-penicillins-h"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset (อาเจียน ท้องเสีย), แพ้ยา (ผื่น anaphylaxis ได้น้อย), เปลี่ยนแปลง gut flora",
      "cites": [
        "vca-ampicillin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Susceptible bacterial infection",
      "route": "IV",
      "dose": "10–20 mg/kg IV/IM/SC ทุก 6–8 ชั่วโมง (รูปฉีด); 20–40 mg/kg PO ทุก 8 ชม. แต่ดูดซึมต่ำ",
      "cites": [
        "merck-penicillins-h",
        "vca-ampicillin"
      ]
    },
    {
      "species": "feline",
      "indication": "Susceptible bacterial infection",
      "route": "IV",
      "dose": "10–20 mg/kg IV/IM/SC ทุก 6–8 ชั่วโมง",
      "cites": [
        "merck-penicillins-h"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-penicillins-h",
      "type": "textbook",
      "title": "Penicillins — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/penicillins",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vca-ampicillin",
      "type": "monograph",
      "title": "Ampicillin — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/ampicillin",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-ampicillin",
      "type": "monograph",
      "title": "Ampicillin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Ampicillin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01CA01",
      "name": "Ampicillin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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