Verify Amlodipine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "amlodipine",
  "nameEn": "Amlodipine",
  "nameTh": "แอมโลดิพีน",
  "class": "Calcium channel blocker — dihydropyridine (first-line feline hypertension)",
  "mechanism": "ยาปิดกั้น L-type calcium channel กลุ่ม dihydropyridine ออกฤทธิ์ขยายหลอดเลือดแดงส่วนปลายเป็นหลัก ลดความดันโลหิต; เป็นยาเลือกแรกสำหรับ systemic hypertension ในแมว",
  "brandNamesTh": [
    "Norvasc"
  ],
  "indications": [
    {
      "text": "systemic hypertension โดยเฉพาะในแมว (มักสัมพันธ์กับ CKD หรือ hyperthyroidism) — เป็นยาเลือกแรก; ใช้ในสุนัขเป็นยาเสริมลดความดัน",
      "cites": [
        "tufts-cardiorush",
        "merck-antiarrhythmics"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในภาวะความดันต่ำ; ค่อย ๆ ปรับขนาด (titrate) เฝ้าระวัง hypotension; รักษาสาเหตุพื้นฐาน (CKD/hyperthyroid) ร่วมด้วย",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำเกินไป, ซึม; gingival hyperplasia เมื่อใช้นานในบางตัว; โดยรวมทนได้ดี",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Systemic hypertension",
      "route": "PO",
      "dose": "0.625–1.25 mg/ตัว PO ทุก 12–24 ชั่วโมง (เริ่มต่ำแล้วปรับขึ้น)",
      "cites": [
        "tufts-cardiorush"
      ]
    },
    {
      "species": "canine",
      "indication": "Hypertension (adjunct)",
      "route": "PO",
      "dose": "0.1–0.2 mg/kg PO ทุก 12 ชั่วโมง หรือ 0.2–0.4 mg/kg ทุก 24 ชั่วโมง",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmics",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.msdvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Merck — beta-blocker, sotalol, Ca-channel-blocker dosing. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-cardiorush",
      "type": "guideline",
      "title": "Cardiology Drug Formulary — Tufts CardioRush",
      "year": 2024,
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "note": "Tufts Cummings veterinary cardiology academic formulary. Authoritative reference for cardiac dosing.",
      "cid": null
    },
    {
      "id": "dailymed-amlodipine",
      "type": "regulatory-database",
      "title": "Amlodipine — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=amlodipine",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "e5382152f9cb6c86229e3b25f3db869df5980f78cbcb424e6d3d20b2d28f4057"
    },
    {
      "id": "atc-C08CA01",
      "type": "guideline",
      "title": "ATC C08CA01 — Amlodipine",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=C08CA01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "751c7aa17ff75256ee22597f11096d5d99a69378d7e4fcbb65f3e502a5a4c535"
    },
    {
      "id": "pubchem-amlodipine",
      "type": "monograph",
      "title": "Amlodipine — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Amlodipine",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "36fc59d399cddd85c2c2664820f4ef3de10a956b0e4eb87c26bf32837a3e9e13"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=amlodipine",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=C08CA01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Amlodipine",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "e5382152f9cb6c86229e3b25f3db869df5980f78cbcb424e6d3d20b2d28f4057",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "751c7aa17ff75256ee22597f11096d5d99a69378d7e4fcbb65f3e502a5a4c535",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "36fc59d399cddd85c2c2664820f4ef3de10a956b0e4eb87c26bf32837a3e9e13",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "C08CA01",
      "name": "Amlodipine",
      "level": 5
    },
    "rxnorm": {
      "cui": "17767",
      "name": "Amlodipine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC C08CA01 + RxNorm 17767. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — amlodipine cat 0.625–1.25 mg/cat (first-line feline hypertension), dog 0.1–0.2 mg/kg q12h verified against Tufts CardioRush + Merck. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ],
  "monitoring": [
    {
      "text": "วัดความดันโลหิตเป็นระยะระหว่างปรับขนาด; ตรวจค่าไตในสัตว์ CKD",
      "cites": [
        "tufts-cardiorush"
      ]
    }
  ]
}

Public keys used

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