Verify Amiodarone

Drug JSON

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{
  "slug": "amiodarone",
  "nameEn": "Amiodarone",
  "nameTh": "อะมิโอดาโรน",
  "class": "Cardiovascular — class III antiarrhythmic",
  "mechanism": "class III antiarrhythmic — ปิดกั้น potassium channel เป็นหลัก (ยืด repolarization/refractory period) ร่วมกับฤทธิ์ class I/II/IV; ใช้คุมการเต้นผิดจังหวะที่ดื้อยาทั้ง ventricular และ supraventricular",
  "brandNamesTh": [
    "Cordarone",
    "Pacerone"
  ],
  "indications": [
    {
      "text": "ventricular tachycardia/arrhythmia ที่ดื้อยา, atrial fibrillation, supraventricular tachycardia ในสุนัข — มักใช้เมื่อ sotalol/mexiletine ไม่พอ",
      "cites": [
        "merck-antiarrhythmic-q",
        "tufts-amiodarone"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ พิษหลายระบบเมื่อใช้นาน — ตับ (เอนไซม์สูง/ตับอักเสบ), ปอด (pulmonary fibrosis), ไทรอยด์, ผิวหนัง; ⚠️ ปฏิกิริยา anaphylactoid ขณะให้ IV; ยับยั้ง CYP เพิ่มระดับ digoxin/อื่น ๆ; เริ่ม low + titrate",
      "cites": [
        "merck-antiarrhythmic-q",
        "tufts-amiodarone"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset, ตับเอนไซม์สูง/hepatotoxicity, ปอดอักเสบ, ไทรอยด์ผิดปกติ, IV reaction; ผลข้างเคียงสะสมตามขนาดรวม",
      "cites": [
        "merck-antiarrhythmic-q"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Refractory VT / AF (loading then maintenance)",
      "route": "PO",
      "dose": "loading 10–20 mg/kg PO วันละครั้ง 7–10 วัน แล้ว maintenance 3–15 mg/kg PO ทุก 24–48 ชม.; acute IV 2 mg/kg ช้า ๆ (ซ้ำได้)",
      "cites": [
        "merck-antiarrhythmic-q",
        "tufts-amiodarone"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าตับ + T4 เป็นระยะ; ECG; เฝ้าอาการทางปอด; เริ่มขนาดต่ำ titrate ช้า",
      "cites": [
        "merck-antiarrhythmic-q"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmic-q",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-amiodarone",
      "type": "guideline",
      "title": "Amiodarone — Tufts CardioRush Cardiology Drug Formulary",
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "year": 2024,
      "note": "Tufts cardiology reference dosing.",
      "cid": null
    },
    {
      "id": "wikipedia-amiodarone",
      "type": "monograph",
      "title": "Amiodarone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Amiodarone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01BD01",
      "name": "Amiodarone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / FDA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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