Verify Aminophylline

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "aminophylline",
  "nameEn": "Aminophylline",
  "nameTh": "อะมิโนฟิลลีน",
  "class": "Respiratory — methylxanthine bronchodilator",
  "mechanism": "สารประกอบ theophylline + ethylenediamine — ยับยั้ง phosphodiesterase (เพิ่ม cAMP) และต้าน adenosine ทำให้กล้ามเนื้อเรียบหลอดลมคลายตัว; กระตุ้นการหายใจและการขับเสมหะ",
  "brandNamesTh": [
    "Aminophylline"
  ],
  "indications": [
    {
      "text": "หลอดลมหดเกร็ง/หลอดลมอักเสบเรื้อรัง, โรคหืดแมว, หลอดลมตีบ (collapsing trachea adjunct) ในสุนัขและแมว — bronchodilator แบบกิน/ฉีด (systemic)",
      "cites": [
        "merck-airway-o",
        "petplace-aminophylline"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ดัชนีความปลอดภัยแคบ — ระวังพิษ (tachycardia, ชัก, อาเจียน) โดยเฉพาะร่วม fluoroquinolone (เพิ่มระดับ theophylline); ระวังในโรคหัวใจ/ลมชัก; ปรับในตับบกพร่อง",
      "cites": [
        "merck-airway-o",
        "petplace-aminophylline"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นเร็ว/ผิดจังหวะ, กระสับกระส่าย, อาเจียน, ปัสสาวะมาก, ชัก (พิษ); แคบระหว่างขนาดรักษากับพิษ",
      "cites": [
        "petplace-aminophylline"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Bronchospasm / chronic bronchitis",
      "route": "PO",
      "dose": "6–11 mg/kg PO/IV (ช้า) ทุก 8 ชั่วโมง",
      "cites": [
        "merck-airway-o",
        "petplace-aminophylline"
      ]
    },
    {
      "species": "feline",
      "indication": "Asthma / bronchospasm",
      "route": "PO",
      "dose": "5 mg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "petplace-aminophylline"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-airway-o",
      "type": "textbook",
      "title": "Systemic Treatment of Inflammatory Airway Disease in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-respiratory-system/systemic-treatment-of-inflammatory-airway-disease-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-aminophylline",
      "type": "monograph",
      "title": "Aminophylline for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/aminophylline-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-aminophylline",
      "type": "monograph",
      "title": "Aminophylline — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Aminophylline",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "R03DA05",
      "name": "Aminophylline",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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