Verify Amikacin

Drug JSON

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{
  "slug": "amikacin",
  "nameEn": "Amikacin",
  "nameTh": "อะมิคาซิน",
  "class": "Antibiotic — aminoglycoside (bactericidal, broad gram-negative)",
  "mechanism": "aminoglycoside จับ 30S ribosome ยับยั้งการสร้างโปรตีน ฆ่าเชื้อแบบ concentration-dependent; ทนต่อ aminoglycoside-inactivating enzyme ได้ดีกว่า gentamicin จึงครอบคลุมเชื้อดื้อกว้างขึ้น",
  "brandNamesTh": [
    "Amiglyde-V",
    "Amikacin K-9"
  ],
  "indications": [
    {
      "text": "ติดเชื้อ gram-negative รุนแรง/ดื้อยา รวม Pseudomonas และเชื้อที่ดื้อ gentamicin; ใช้ในภาวะ sepsis และการติดเชื้อซับซ้อนภายใต้การติดตาม",
      "cites": [
        "merck-aminoglycoside-b",
        "fda-amikacin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ เป็นพิษต่อไตและหูเช่นเดียวกับ aminoglycoside อื่น (โดยรวมพิษไตน้อยกว่า gentamicin เล็กน้อย) — ระวังในไตบกพร่อง/ขาดน้ำ; ให้วันละครั้ง",
      "cites": [
        "merck-aminoglycoside-b"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พิษต่อไต (ATN), ototoxicity, neuromuscular blockade; เฝ้าระวังเช่นเดียวกับ gentamicin",
      "cites": [
        "merck-aminoglycoside-b"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Severe / resistant gram-negative infection",
      "route": "IV",
      "dose": "15–30 mg/kg IV (ช้า ๆ)/IM/SC วันละครั้ง",
      "cites": [
        "fda-amikacin",
        "merck-aminoglycoside-b"
      ]
    },
    {
      "species": "feline",
      "indication": "Severe / resistant gram-negative infection",
      "route": "IV",
      "dose": "10–15 mg/kg IV (ช้า ๆ)/IM/SC วันละครั้ง",
      "cites": [
        "merck-aminoglycoside-b"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจค่าไตและ urine sediment ก่อน/ระหว่างใช้; ดูแลน้ำให้พอ; ระยะเวลายาสั้นที่สุด",
      "cites": [
        "merck-aminoglycoside-b"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-aminoglycoside-b",
      "type": "textbook",
      "title": "Aminoglycosides — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/aminoglycosides-and-aminocyclitols",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "fda-amikacin",
      "type": "package-insert",
      "title": "Amikacin K-9 Injection — FDA veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/amikacin-k-9-injection.html",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "wikipedia-Amikacin",
      "type": "monograph",
      "title": "Amikacin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Amikacin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01GB06",
      "name": "Amikacin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / AAHA + ACVIM guidelines / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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