Verify Alfaxalone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "alfaxalone",
  "nameEn": "Alfaxalone",
  "nameTh": "อัลแฟกซาโลน",
  "class": "Anesthetic — neuroactive steroid IV induction agent (veterinary)",
  "mechanism": "ยาสลบฉีดกลุ่ม neuroactive steroid เสริมการทำงาน GABA-A receptor ทำให้สลบ; ออกฤทธิ์เร็ว ฟื้นเร็ว ผลต่อหัวใจและหลอดเลือดน้อยกว่า propofol บ้าง; สำหรับสัตว์โดยเฉพาะ (Alfaxan)",
  "brandNamesTh": [
    "Alfaxan",
    "Alfaxan Multidose"
  ],
  "indications": [
    {
      "text": "นำสลบ (induction) ทางหลอดเลือดดำในสุนัขและแมว และคงสภาพสลบด้วย CRI; ทางเลือกแทน propofol โดยเฉพาะในสัตว์ที่ต้องการฟื้นเร็ว",
      "cites": [
        "cb-alfaxalone",
        "fda-alfaxan"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในสัตว์ที่ระบบหัวใจ/หลอดเลือดไม่คงที่; ฉีดเร็วทำให้หยุดหายใจ; ฟื้นในที่เงียบ (อาจมี excitement ถ้าไม่ได้ premedication)",
      "cites": [
        "cb-alfaxalone"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดการหายใจ (apnea หากฉีดเร็ว), ความดันต่ำเล็กน้อย; rough recovery หากไม่ได้ premedication",
      "cites": [
        "cb-alfaxalone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "IV induction",
      "route": "IV",
      "dose": "ไม่ได้ premedication 2 mg/kg IV (ช่วง 1.5–4.5); ได้ premedication 1–2 mg/kg IV ค่อย ๆ ฉีดจนได้ผล",
      "cites": [
        "cb-alfaxalone",
        "fda-alfaxan"
      ]
    },
    {
      "species": "feline",
      "indication": "IV induction",
      "route": "IV",
      "dose": "ไม่ได้ premedication 5 mg/kg IV; ได้ premedication 2–4 mg/kg IV จนได้ผล",
      "cites": [
        "cb-alfaxalone",
        "fda-alfaxan"
      ]
    }
  ],
  "citations": [
    {
      "id": "cb-alfaxalone",
      "type": "guideline",
      "title": "Reintroduced Anesthetic Alfaxalone — Clinician's Brief",
      "year": 2024,
      "url": "https://www.cliniciansbrief.com/article/reintroduced-anesthetic-alfaxalone",
      "note": "Peer-reviewed clinical reference — dog 2 mg/kg, cat 5 mg/kg IV induction.",
      "cid": null
    },
    {
      "id": "fda-alfaxan",
      "type": "package-insert",
      "title": "Alfaxan (alfaxalone) — FDA-approved veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/alfaxan-alfaxalone-10-mg-ml.html",
      "note": "FDA-approved veterinary product label. Public FDA labeling.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QN01AX05",
      "name": "Alfaxalone (veterinary)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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