Verify Aciclovir (acyclovir)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "acyclovir",
  "nameEn": "Aciclovir (acyclovir)",
  "nameTh": "อะไซโคลเวียร์",
  "class": "Antiviral — nucleoside analogue (herpesvirus)",
  "mechanism": "nucleoside analogue — ถูก phosphorylate โดย viral thymidine kinase แล้วยับยั้ง viral DNA polymerase หยุดการจำลอง herpesvirus; ประสิทธิภาพต่อ feline herpesvirus จำกัด (poor potency + bioavailability)",
  "brandNamesTh": [
    "Zovirax"
  ],
  "indications": [
    {
      "text": "feline herpesvirus-1 (FHV-1) — ใช้ได้แต่ประสิทธิภาพจำกัด; ⚠️ ปัจจุบัน famciclovir เป็นทางเลือกที่ดีและปลอดภัยกว่ามาก สำหรับ FHV-1",
      "cites": [
        "everycat-fhv",
        "paper-acyclovir"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ เป็นพิษต่อแมว (กดไขกระดูก) เมื่อให้ systemic + bioavailability ต่ำ (ระดับยาไม่ถึง IC50 ของ FHV-1) — โดยรวม \"ควรหลีกเลี่ยง\" ในแมว, ใช้ famciclovir แทน; ตรวจ CBC หากจำเป็นต้องใช้",
      "cites": [
        "paper-acyclovir",
        "everycat-fhv"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "⚠️ bone marrow suppression (ตรวจ CBC), GI upset, พิษไต; แมวไวต่อพิษ + ดูดซึมแย่",
      "cites": [
        "paper-acyclovir"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "FHV-1 (limited efficacy — famciclovir preferred)",
      "route": "PO",
      "dose": "10–25 mg/kg PO วันละ 2 ครั้ง — ⚠️ ประสิทธิภาพจำกัด + เสี่ยงพิษ, พิจารณา famciclovir แทน",
      "cites": [
        "everycat-fhv",
        "paper-acyclovir"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC (กดไขกระดูก) หากใช้ systemic; เฝ้าค่าไต",
      "cites": [
        "paper-acyclovir"
      ]
    }
  ],
  "citations": [
    {
      "id": "everycat-fhv",
      "type": "guideline",
      "title": "Evaluating treatments for feline herpesvirus type 1 — EveryCat Health Foundation",
      "url": "https://everycat.org/cat-health/evaluating-treatments-for-feline-herpesvirus-type-1/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "paper-acyclovir",
      "type": "paper",
      "title": "A review of antiviral drugs with activity against feline herpesvirus-1",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4930706/",
      "year": 2023,
      "note": "Peer-reviewed FHV-1 antiviral review.",
      "cid": null
    },
    {
      "id": "wikipedia-aciclovir",
      "type": "monograph",
      "title": "Aciclovir — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Aciclovir",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J05AB01",
      "name": "Aciclovir",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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