Verify Acetazolamide

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "acetazolamide",
  "nameEn": "Acetazolamide",
  "nameTh": "อะเซตาโซลาไมด์",
  "class": "Ophthalmology — systemic carbonic anhydrase inhibitor",
  "mechanism": "carbonic anhydrase inhibitor ชนิดกิน/ฉีด — ลดการสร้าง bicarbonate ที่ ciliary body จึงลดการสร้าง aqueous humor และความดันลูกตา; มีฤทธิ์ขับปัสสาวะอ่อน ๆ ด้วย",
  "brandNamesTh": [
    "Diamox",
    "Dazamide"
  ],
  "indications": [
    {
      "text": "ต้อหิน (glaucoma) ลดความดันลูกตาในสุนัขและแมว (มักเสริมยาหยอด); ใช้น้อยลงเพราะผลข้างเคียง systemic — ปัจจุบันนิยม topical CAI (dorzolamide) มากกว่า",
      "cites": [
        "merck-glaucoma",
        "petplace-acetazolamide"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ แมวไวต่อ metabolic acidosis มาก — ใช้ระวังสุด; ทำให้ hypokalemia + hyperchloremic acidosis; ห้ามในไต/ตับบกพร่อง, แพ้ sulfonamide, Addison; PU/PD",
      "cites": [
        "merck-glaucoma",
        "petplace-acetazolamide"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "PU/PD, GI upset, หอบ, metabolic acidosis, K+ ต่ำ, ซึม; แมวเสี่ยงพิษมากกว่าสุนัข",
      "cites": [
        "petplace-acetazolamide"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Glaucoma (adjunct)",
      "route": "PO",
      "dose": "4–8 mg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "merck-glaucoma",
        "petplace-acetazolamide"
      ]
    },
    {
      "species": "feline",
      "indication": "Glaucoma (extreme caution)",
      "route": "PO",
      "dose": "4–8 mg/kg PO ทุก 8–12 ชั่วโมง — ⚠️ ระวัง metabolic acidosis",
      "cites": [
        "petplace-acetazolamide"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-glaucoma",
      "type": "textbook",
      "title": "Glaucoma in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/eye-and-ear/glaucoma/glaucoma-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-acetazolamide",
      "type": "monograph",
      "title": "Acetazolamide (Diamox) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/acetazolamide-diamox-dazamide-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-acetazolamide",
      "type": "monograph",
      "title": "Acetazolamide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Acetazolamide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "S01EC01",
      "name": "Acetazolamide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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