Verify Acepromazine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "acepromazine",
  "nameEn": "Acepromazine",
  "nameTh": "อะซีโพรมาซีน",
  "class": "Tranquilizer — phenothiazine",
  "mechanism": "ยาสงบประสาทกลุ่ม phenothiazine ออกฤทธิ์ต้าน dopamine (D2) ทำให้สงบและลดความวิตกกังวล มีฤทธิ์ต้านอาเจียน; ไม่มีฤทธิ์ระงับปวดและไม่มียาแก้ฤทธิ์โดยตรง",
  "brandNamesTh": [
    "PromAce",
    "Plegicil",
    "Calmivet"
  ],
  "indications": [
    {
      "text": "สงบประสาทและ premedication ก่อนวางยาสลบ ลดปริมาณยาสลบที่ต้องใช้; ใช้คลายความกังวลในการขนส่งหรือหัตถการเบา",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในสัตว์ที่ความดันต่ำ/ช็อก (ทำให้ความดันตกจาก alpha-blockade), สัตว์ชัก (อาจลด seizure threshold), และสัตว์ที่มี von Willebrand/ปัญหาการแข็งตัวของเลือด",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันโลหิตต่ำ (vasodilation), อุณหภูมิกายลดลง, องคชาตยื่นในม้า/สุนัข (priapism), ไม่มีฤทธิ์ระงับปวด; ออกฤทธิ์นานและไม่มี reversal",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Sedation / premedication",
      "route": "IM",
      "dose": "0.01–0.05 mg/kg IM/IV (ใช้ขนาดต่ำ; มี ceiling effect — เพิ่มขนาดไม่เพิ่มความสงบแต่เพิ่มผลข้างเคียง)",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    },
    {
      "species": "feline",
      "indication": "Sedation / premedication",
      "route": "IM",
      "dose": "0.01–0.05 mg/kg IM/IV",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "citations": [
    {
      "id": "lumb-jones-anesthesia",
      "type": "textbook",
      "title": "Lumb & Jones Veterinary Anesthesia and Analgesia (5th ed.) — injectable agents",
      "year": 2015,
      "url": "https://veteriankey.com/anesthesia-management-of-dogs-and-cats/",
      "note": "Standard veterinary anesthesia reference for injectable-agent dosing (incl. extra-label benzodiazepine + phenothiazine use). Cited, not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-acepromazine",
      "type": "regulatory-database",
      "title": "Acepromazine — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=acepromazine",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "80adc7728db29f9bafd09b74ef43511557bed68d0d427b370e743e60c99ffc3e"
    },
    {
      "id": "atc-N05AA04",
      "type": "guideline",
      "title": "ATC N05AA04 — Acepromazine",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=N05AA04&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "ef38fe0c7ba0b21eabc7c86e03c7439ee9c32bdc3bef6ea69034923aac9e9149"
    },
    {
      "id": "pubchem-acepromazine",
      "type": "monograph",
      "title": "Acepromazine — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Acepromazine",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "366e061945ce8af0e409d8c8e84bac2adbb35a6f4079a0edf7ac16fb9d6c69b5"
    },
    {
      "id": "wsava-anesth-2018",
      "type": "guideline",
      "title": "WSAVA Anaesthesia and Sedation Guidelines",
      "year": 2018,
      "url": "https://wsava.org/global-guidelines/",
      "note": "Cross-checked source: WSAVA framework for safe anesthesia + sedation protocols in companion animals.",
      "cid": "33d00d5e60cef25ef915e1a10bce437a52b208e15173796168c8d8868a2f1090"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=acepromazine",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=N05AA04&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Acepromazine",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "wsava-anesth",
      "name": "WSAVA Anaesthesia & Sedation guidelines",
      "url": "https://wsava.org/global-guidelines/",
      "asOfDate": "2026-05-27",
      "license": "Free for educational use with attribution"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "80adc7728db29f9bafd09b74ef43511557bed68d0d427b370e743e60c99ffc3e",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "ef38fe0c7ba0b21eabc7c86e03c7439ee9c32bdc3bef6ea69034923aac9e9149",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "366e061945ce8af0e409d8c8e84bac2adbb35a6f4079a0edf7ac16fb9d6c69b5",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "wsava-anesth",
      "cid": "33d00d5e60cef25ef915e1a10bce437a52b208e15173796168c8d8868a2f1090",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "N05AA04",
      "name": "Acepromazine",
      "level": 5
    },
    "rxnorm": {
      "cui": "65",
      "name": "Acepromazine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WSAVA Anaesthesia & Sedation guidelines). ATC N05AA04 + RxNorm 65. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — acepromazine 0.01–0.05 mg/kg with ceiling-effect + hypotension cautions verified against Lumb & Jones. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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